Biomedical Materials

Developing advanced biomaterials and biomanufacturing technologies for the next generation of repair and regenerative therapies in orthopaedics


Dr Matteo D' Este

Focus Area Leader:
Biomedical Materials

Profile page

The Biomedical Materials focus area is committed to the design of advanced biomaterials and the development of (bio)manufacturing technologies to achieve improved patient care and outcomes in musculoskeletal disorders. Using variety of chemical approaches, we create responsive biomaterials that react to environmental stimuli and actively interact with cells and tissues.

We design biomaterial surfaces and antibacterial delivery systems for prevention and treatment of infections, and we are investigating how materials "talk" to the body at the cellular level by harnessing the inflammatory processes to trigger a healing response and prevent chronic inflammation. We also develop bio-processing technologies for translating tissue engineering approaches to regenerative, patient-tailored precision medicine.

By deepening our understanding on how materials dynamically interact with/in the body, and how additive manufacturing and bioprocessing modulate these interactions, we aim to advance orthopaedic patient care.


Selected collaborative projects

  • 2020-2023- Precision medicine for musculoskeletal regeneration, prosthetics and active ageing. (PREMUROSA Innovative Training Networks, partner, H2020 funded project, nber: 860462).
  • 2020-2024- Engineered full-organ 3D intervertebral disc as standardized model for studying disc degeneration and disease. (INDEED, coordinator SNF-ANR Bilateral project, nber: 310030E_189310).
  • 2020-2024- 3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients. (cmRNAbone, coordinator H2020 funded project, nber: 874790).
  • 2020-2026- Establishment of the Baltic Biomaterials Centre of Excellence. (partner, H2020 funded project, number 857287).


Selected scientific publications

Other focus areas

Progenitor Cell Biology and Mechanoregulation

Disc and Cartilage Biology

Sound Guided Tissue Regeneration

Bone Biology

Infection Biology

Meet the team

See more about the team on the Regenerative Orthopaedics research program