Young PREMUROSA researchers present their musculoskeletal disorder research projects

AO Research Institute Davos (ARI) scientists and other partners of PREMUROSA—the Marie Sklodowska-Curie Innovative Training Network—recently met the 13 young researchers who are investigating new technologies and therapies for musculoskeletal disorders as part of the PREMUROSA initiative. The online meeting, in which the young researchers presented their early-stage research projects, was a highlight of PREMUROSA’s first network school, October 19–23.

ARI Vice Director Mauro Alini, PhD, and ARI research scientist Tiziano Serra, PhD, are supervising a PREMUROSA early-stage research (ESR) project focused on design of a 3D in vitro vascularized organoid model. The project, hosted by ARI, aims to:

• Develop in vitro 3D organoid models able to study patient specific tissue behaviour for potential novel treatment and/or implementation in regulatory process.

• Obtain in vitro safety/efficacy data on the “specific treatment” using the developed 3D organoid models and compare with in vivo data.
• Learn the bioprinting process for the generation of 3D organoid models.
• Develop, print and characterize bioinks for 3D organoid models.
• Produce perfusable tubular, vascular networks within the 3D organoid models.
• Establish 3D organoid models’ functionality in terms of ability to read out response to drug 

The four-year PREMUROSA initiative, which began in January 2020, is training a new generation of scientists with an integrated vision of the whole value chain in musculoskeletal regeneration technologies and seeking to boost innovations necessary to achieve precision principles in developing innovative devices and optimized clinical applications.

To learn more about the ESR projects, please visit: https://premurosa.eu/news/