Clinical Evidence Current Studies

Find out more about the 45 studies we are currently running in 40 countries.

Current studies

  • AO Trauma
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    PPFx Registry

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty

    Karl Stoffel

    2023

    Monitoring

    CPP Patient Outcome Project I

    Clinical Priority Program (CPP) Patient Outcome Project I:
    Translation, Cultural Adaptation and Cognitive Debriefing of Extension Items of PROMIS Physical Function item bank V2.0 in German and Spanish

    Marilyn Heng, Claudia Hartmann

    2024

    Planning

    CPP Patient Outcome Project II

    Clinical Priority Program (CPP Patient Outcome Project II:
    GO FIT FAST - Gait Observation for Fully Individualized Treatment and Aftercare following Surgery and Trauma

    Tim Pohlemann, Benedikt Braun

    2024

    Monitoring

    CPP Patient Outcome Project III

    Clinical Priority Program (CPP) Patient Outcome Project III:
    Development of interpretation guidance for clinicians to better understand meaning of PROMIS scores

    Prakash Jayakumar, Marilyn Heng, Stephen Gwilym

    2024

    Monitoring

    CPP Patient Outcome Project IV

    Clinical Priority Program (CPP) Patient Outcome Project IV:
    Linking of PROMIS Physical Function to Legacy Measures in an Orthopaedic Patient Population

    Marilyn Heng (center 1),
    Tim Pohlemann, Benedikt Braun (Center 2), Prakash Jayakumar (Center 3)

    2024

    Monitoring

    CPP Patient Outcome Project V

    Clinical Priority Program (CPP) Patient Outcome Project V:
    Norm Data - Collection of international Age-based Norm Data for interpretation of scores obtained from the newly extended PROMIS® Physical Function item bank version 2.0

    Matthias Rose

    2024

    Monitoring

    CPP Patient Outcome Project VI

    Clinical Priority Program (CPP) Patient Outcome Project VI:
    Standard setting to develop PROMIS score severity threshold categories

    Marilyn Heng

    2024

    Monitoring

    AOFFP Fragility Fractures of the Pelvis: Observational Outcome Study Pol Maria Rommens 2024 Monitoring
    PedOrtho A prospective multicenter observational registry of pediatric orthopedic trauma and health outcomes in skeletally immature children Kishore Mulpuri 2026 Monitoring
  • AO Spine
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    EPOSO

    The epidemiology, process and outcomes of spine oncology

    Charles Fisher

    2022

    Publication

    SDIM

    Spinal deformity intraoperative monitoring: understanding and managing intraoperative neuromonitoring changes during spinal deformity surgery

    Stephen Lewis

    2022

    Monitoring

     PEEDS

    Prospective evaluation of elderly deformity surgery

    Stephen Lewis

    2022

    Analysis

    MTRON

    Metastatic tumor research and outcomes network: a multicenter prospective registry for the management of metastatic spine tumors

    Charles Fisher

    2024

    Monitoring

    PTRON

    Primary tumor research and outcomes network: A multicenter prospective registry for the management of primary tumors of the spine

    Jeremy Reynolds

    2024

    Monitoring

    DegenPRO

    Spine registry to collect outcome measures related to the disease status of patients with dpine disorders

    Tim Yoon

    2024

    Monitoring

    Spine_TL-A3-A4

    Thoracolumbar burst fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment

    Marcel Dvorak

    2022

    Monitoring

    SCI POEM

    Prognostic factors and therapeutic effects of surgical treatment for traumatic spinal column iInjury with spinal cord injury

    Allard Hosman

    2022

    Publication

    INTWIN

    Traumatic incomplete tetraplegia without instability: a prospective multicenter feasibility study of outcomes and prognosis

    Jefferson R Wilson

    2026

    Planning

  • AO CMF
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    MRONJ registry

    An international, multicenter, prospective registry to collect data of treatment patterns of patients with Medication-Related OsteoNecrosis of the Jaw (MRONJ) and their outcome

    Risto Kontio (University of Helsinki) and Sven Otto (Ludwig-Maximilian University, Munich)

    2024

    Monitoring

    BCFx registry

    International, multicenter, prospective registry to collect data of treatment patterns in patients with bilateral condylar fracture (BCFx) of the mandible

    Risto Kontio (University of Helsinki) and Edward Ellis 3rd (University of Texas Health Science Center at San Antonio)

    2024

    Monitoring

    OFx

    International, multicenter, prospective registry to collect data on orbital fractures (OFx), their treatment and outcome

    Eppo B Wolvius

    2026

    Monitoring

    MFx 60+

    International, multicenter, prospective registry to collect data in patients > 60 years suffering from mandibular fractures

    Risto Kontio

    2025

    Monitoring

    TMJ replacements

    International, multicenter, prospective registry to collect data of patients treated with alloplastic temporomandibular joint (TMJ) replacements

    Andreas Thor

    2028

    Monitoring

  • AO Technical Commission
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    TROLLEY
    Evaluation of a growth guiding construct vs. standard dual growing rods and VEPTR for the treatment of early onset scoliosis patients: A prospective multi-center cohort study with a matched historical control.
     
    Jean Ouellet, MD, FRCSC
    2029 Monitoring
    FR Tomofix
    A focused registry on the conservative treatment of osteoarthritis of the knee 
    Takeshi Sawaguchi
    Q4 2022 Publication
    Moticon - HTO

    OpenGo Sensor Insole in open wedge HTO

    Stefan Döbele, Steffen Schröter

    Q3 2022             

    Monitoring

    PedFemFx

    A prospective multicenter observational registry for children up to 16 years of age with femur shaft fractures

    Peter Schmittenbecher, Unni Narayanan

    Q2 2022             

    Monitoring

    FR FNS

    A focused registry on the Femoral Neck System (FNS) in patients with femoral neck fractures

    Karl Stoffel

    Q2 2022             

    Publication

    EPOCA

    A randomized multicenter study comparing the effectiveness of hemi versus total shoulder arthroplasty in patients with a degenerative joint disease

    Norbert Suedkamp

    Q2 2022             

    Monitoring

    PPFx Registry

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty

    Karl Stoffel

    2023             

    Monitoring

    VA-LCP Case review
    Locking plates for distal femur fractures – a multicenter case review
    A retrospective radiological analysis of the mechanical performance of different locking plates in distal femoral fractures             

    Mark Lee

    2022

    Monitoring

    LoBoDeRe

    An international, multicenter, prospective registry to investigate treatment options and their outcomes on Long Bones Defects

    Christoph Pape

    Q2 2026             

    Planning

    FROST

    Fracture-Related Outcome Study for operatively treated Tibia shaft fractures

    Willem-Jan Metsemakers

    Q4 2024             

    Monitoring

    CMF distractor

    Multicenter registry on indications, safety and clinical outcome of internal univector and curvilinear distraction devices in the treatment of congenital and acquired deformities of the craniomaxillofacial (CMF) skeleton

    Richard A Hopper
    Q4 2025 Planning
    SMDR Registry International, multicenter, prospective registry to collect data on treatment, outcome, and complications subsequent to reconstruction of acquired segmental mandibular defects in oral squamous cell carcinoma patients - SMDR (Segmental Mandibular Defect Reconstruction) registry
     
    Rüdiger M Zimmerer
    Q1 2027 Planning
    MatrixWAVE
    An International, Multicenter, Focused Registry to collect clinical data on the MatrixWAVE Mandibulo-Maxillary Fixation System
     
    Carl-Peter Cornelius
    Q2 2023 Monitoring
    VA Clavicle Observational case series on the clinical performance of the DePuy Synthes Variable Angle Clavicle Plate and Clavicle Hook Plate 2.7 Systems
     
    Simon Lambert 2025
    Planning
  • AO Education Institute
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    Immpact

    Development of performance metrics for cephalomedullary nailing for unstable pertrochanteric fractures- phase 1

    Anthony Gallagher

    n/a

    Montoring

  • AO Development Incubator
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    Fracture Monitor

    Prospective case series to analyze safety data in femoral and proximal tibial fracture patients treated with a locking compression plate with an attached investigational Fracture Monitor (Fracture Monitor-Femur/Proximal Tibia)

    Bendikt Braun

    n/a

    Planning

  • Collaboration with the AO Research Institute Davos (ARI)
    Short title 

    Project title

    Principal coordinating investigator

    Project ending

    Current phase

    SmartPlate

    Next generation SmartFix-integration with implants

    n/a

    n/a

    Idea

Find out more

Clinical Research Fellowship

Apply now to take part in a clinical research fellowship at the AO's Innovation Translation Center.

Innovation Translation Center

Innovation translation at the AO involves developing disruptive technologies to address unmet clinical needs.

Clinical Science

Clinical evidence generated through AO clinical studies can be accessed in the form of journal articles, presentations at scientific meetings, final study reports, guidelines, classifications, and/or news on the AO website.

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