Clinical Evidence Current Studies

Find out more about the 45 studies we are currently running in 40 countries.

Current studies

AO Trauma

Short title	Project title	Principal coordinating investigator	Project ending	Current phase
PPFx Registry	Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty	Karl Stoffel	2023	Monitoring
CPP Patient Outcome Project I	Clinical Priority Program (CPP) Patient Outcome Project I: Translation, Cultural Adaptation and Cognitive Debriefing of Extension Items of PROMIS Physical Function item bank V2.0 in German and Spanish	Marilyn Heng, Claudia Hartmann	2024	Publication
CPP Patient Outcome Project II	Clinical Priority Program (CPP Patient Outcome Project II: GO FIT FAST - Gait Observation for Fully Individualized Treatment and Aftercare following Surgery and Trauma	Tim Pohlemann, Benedikt Braun	2029	Monitoring
CPP Patient Outcome Project III	Clinical Priority Program (CPP) Patient Outcome Project III: Development of interpretation guidance for clinicians to better understand meaning of PROMIS scores	Prakash Jayakumar, Marilyn Heng, Stephen Gwilym	2029	Monitoring
CPP Patient Outcome Project IV	Clinical Priority Program (CPP) Patient Outcome Project IV: Linking of PROMIS Physical Function to Legacy Measures in an Orthopaedic Patient Population	Marilyn Heng (center 1), Tim Pohlemann, Benedikt Braun (Center 2), Prakash Jayakumar (Center 3)	2029	Monitoring
AOFFP	Fragility Fractures of the Pelvis: Observational Outcome Study	Pol Maria Rommens	2029	Monitoring
PedOrtho	A prospective multicenter observational registry of pediatric orthopedic trauma and health outcomes in skeletally immature children	Kishore Mulpuri	2028	Monitoring
(COSTA 2)	Two-stage development of a Core Outcome Set for distal tibia and ankle fractures. COSTA 2, the second stage, seeks to identify the best suitable outcome measurement systems attributed to the defined core domain sets	Kirstie Haywood	2025	Planning

AO Spine

Short title	Project title	Principal coordinating investigator	Project ending	Current phase
EPOSO	The epidemiology, process and outcomes of spine oncology	Charles Fisher	2024	Publication
SDIM	Spinal deformity intraoperative monitoring: understanding and managing intraoperative neuromonitoring changes during spinal deformity surgery	Stephen Lewis	2023	Analysis
PEEDS	Prospective evaluation of elderly deformity surgery	Stephen Lewis	2025	Analysis
MTRON	Metastatic tumor research and outcomes network: a multicenter prospective registry for the management of metastatic spine tumors	Charles Fisher	open ended registry	Monitoring
PTRON	Primary tumor research and outcomes network: A multicenter prospective registry for the management of primary tumors of the spine	Jeremy Reynolds	open ended registry	Monitoring
DegenPRO	Spine registry to collect outcome measures related to the disease status of patients with dpine disorders	Tim Yoon	2024	Monitoring
Spine_TL-A3-A4	Thoracolumbar burst fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment	Marcel Dvorak	2025	Analysis
SCI POEM	Prognostic factors and therapeutic effects of surgical treatment for traumatic spinal column iInjury with spinal cord injury	Allard Hosman	2025	Publication
INTWIN	Traumatic incomplete tetraplegia without instability: a prospective multicenter feasibility study of outcomes and prognosis	Jefferson R Wilson	2027	Planning
I-SCRIBBLE	Spinal Cord Injury Blood Biomarker Longitudinal Evaluation	Brian K. Kwon	2028	Idea
SMART	Durability of supplementary rod constructs—SuppleMentAry Rod Technique (SMART)—for long-segment posterior instrumented spinal fusion procedures: A multicenter retrospective comparative study with dual-rod constructs	Justin Smith	2027	Planning
TL Ofx	The osteoporotic fracture classification-based scoring system for treatment decision in thoracolumbar osteoporotic fractures: An international multicenter prospective study	Klaus Schnake	2028	Idea

AO CMF

Short title	Project title	Principal coordinating investigator	Project ending	Current phase
MRONJ registry	An international, multicenter, prospective registry to collect data of treatment patterns of patients with Medication-Related OsteoNecrosis of the Jaw (MRONJ) and their outcome	Risto Kontion, Sven Otto	2026	Monitoring
BCFx registry	International, multicenter, prospective registry to collect data of treatment patterns in patients with bilateral condylar fracture (BCFx) of the mandible	Risto Kontio, Edward Ellis 3rd	2025	Analysis
OFx	International, multicenter, prospective registry to collect data on orbital fractures (OFx), their treatment and outcome	Eppo B Wolvius	2029	Monitoring
TMJ replacements	International, multicenter, prospective registry to collect data of patients treated with alloplastic temporomandibular joint (TMJ) replacements	Andreas Thor	2031	Monitoring

AO Technical Commission

Short title	Project title	Principal coordinating investigator	Project ending	Current phase
TROLLEY	Evaluation of a growth guiding construct vs. standard dual growing rods and VEPTR for the treatment of early onset scoliosis patients: A prospective multi-center cohort study with a matched historical control.	Jean Ouellet, MD, FRCSC	2029	Monitoring
Moticon - HTO	OpenGo Sensor Insole in open wedge HTO	Steffen Schröter	Q2 2024	Monitoring
PedFemFx	A prospective multicenter observational registry for children up to 16 years of age with femur shaft fractures	Peter Schmittenbecher, Unni Narayanan	2024	Analysis
FR FNS	A focused registry on the Femoral Neck System (FNS) in patients with femoral neck fractures	Karl Stoffel	2024	Analysis
EPOCA	A randomized multicenter study comparing the effectiveness of hemi versus total shoulder arthroplasty in patients with a degenerative joint disease	Norbert Suedkamp, Martin Jäger	Q2 2024	Analysis
PPFx Registry	Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty	Karl Stoffel	2028	Monitoring
VA-LCP Case review	Locking plates for distal femur fractures – a multicenter case review A retrospective radiological analysis of the mechanical performance of different locking plates in distal femoral fractures	Mark Lee	2024	Analysis
LoBoDeRe	An international, multicenter, prospective registry to investigate treatment options and their outcomes on Long Bones Defects	Hans-Christoph Pape	2029	Planning
FROST	Fracture-Related Outcome Study for operatively treated Tibia shaft fractures	Willem-Jan Metsemakers	2027	Monitoring
SMDR Registry	International, multicenter, prospective registry to collect data on treatment, outcome, and complications subsequent to reconstruction of acquired segmental mandibular defects in oral squamous cell carcinoma patients - SMDR (Segmental Mandibular Defect Reconstruction) registry	Rüdiger M Zimmerer	2030	Monitoring
MatrixWAVE	An International, Multicenter, Focused Registry to collect clinical data on the MatrixWAVE Mandibulo-Maxillary Fixation System	Carl-Peter Cornelius	2025	Monitoring
VA Clavicle	Observational case series on the clinical performance of the DePuy Synthes Variable Angle Clavicle Plate and Clavicle Hook Plate 2.7 Systems	Simon Lambert	2027	Planning

AO Education Institute

Short title	Project title	Principal coordinating investigator	Project ending	Current phase
Immpact	Development of performance metrics for cephalomedullary nailing for unstable pertrochanteric fractures- phase 1	Anthony Gallagher	n/a	Analysis

AO Development Incubator

Short title	Project title	Principal coordinating investigator	Project ending	Current phase
Fracture Monitor	Prospective case series to analyze safety data in femoral and proximal tibial fracture patients treated with a locking compression plate with an attached investigational Fracture Monitor (Fracture Monitor-Femur/Proximal Tibia)	Bendikt Braun	2026	Monitoring
(Image AI)	Development of a high quality, annotated data set of proximal femur fractures (31A/31B/31C) to be used for development or testing of AI	Alessandro Aprato	2025	Monitoring

Collaboration with the AO Research Institute Davos (ARI)

Short title	Project title	Principal coordinating investigator	Project ending	Current phase
SmartPlate	Next generation SmartFix-integration with implants	n/a	n/a	Idea
Fracture Monitor	Prospective first-in-human clinical investigation to evaluate the safety of the Fracture Monitor T1 in patients with femur fractures treated with a locking compression plate	Bendikt Braun	2026	Monitoring

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