Clinical Evidence Current Studies

Find out more about the 79 studies we are currently running in 38 countries.

Current studies

  • AO Trauma

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov
    NCT number

    Current Phase

    Implementation of a registry on bone infection to improve patient outcomes and research efforts (CPP Bone Infection Registry)

    Stephen Kates

    NCT01677000

    Analysis

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty (PPFx Registry)

    Karl Stoffel

    NCT03378557

    Monitoring

    A prospective multicenter cohort study to evaluate the benefit of the geriatric fracture center concept (GFC)

    Michael Blauth

    NCT02297581

    Analysis

    A prospective multicenter cohort study to evaluate the effect of early mobilization of patients after hip fracture fixation on functional outcomes in the Chinese population (MobiChina)

    Frankie Leung

    NCT02296086

    Analysis

    MobiChina survey

    Frankie Leung

    n/a

    Monitoring

    Clinical Priority Program (CPP III pre-project prox humerus)

    Laurent Audigé

    n/a

    Analysis

    Clinical Priority Program (CPP) Patient Outcome Project I:
    Translation, Cultural Adaptation and Cognitive Debriefing of Extension Items of PROMIS Physical Function item bank V2.0 in German and Spanish

    Marilyn Heng, Claudia Hartmann

    n/a

    Planning

    Clinical Priority Program (CPP Patient Outcome Project II:
    GO FIT FAST - Gait Observation for Fully Individualized Treatment and Aftercare following Surgery and Trauma

    Tim Pohlemann, Benedikt Braun

    NCT04113044

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project III:
    Development of interpretation guidance for clinicians to better understand meaning of PROMIS scores

    Prakash Jayakumar, Marilyn Heng, Stephen Gwilym

    NCT04113044

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project IV:
    Linking of PROMIS Physical Function to Legacy Measures in an Orthopaedic Patient Population

    Marilyn Heng (center 1),
    Tim Pohlemann, Benedikt Braun (Center 2), Prakash Jayakumar (Center 3)

    NCT04113044

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project V:
    Norm Data - Collection of international Age-based Norm Data for interpretation of scores obtained from the newly extended PROMIS® Physical Function item bank version 2.0

    Matthias Rose

    n/a

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project VI:
    Standard setting to develop PROMIS score severity threshold categories

    Marilyn Heng

    n/a

    Planning

    AO multicenter intervention trial to evaluate the impact of a bundle of measures for the prevention of surgical site infection in fracture patients (AOPOSSI)

    Stephen L. Kates

    NCT03380273

    Planning

    (LAMOS) Latin America hip fracture mortality study

    William Belangero

    NCT01650064

    Publication

     

  • AO Spine

    Project title (short title)

    Principal Coordinating
    Investigator

    Clin.Trial.gov
    NCT number

    Current Phase

    The epidemiology, process and outcomes of spine oncology (EPOSO)

    Charles Fisher

    n/a

    Monitoring

    Spinal deformity intraoperative monitoring: understanding and managing intraoperative neuromonitoring changes during spinal deformity surgery (SDIM)

    Stephen Lewis

    NCT03880292

    Monitoring

    Prospective evaluation of elderly deformity surgery (PEEDS)

    Stephen Lewis

    NCT02035280

    Monitoring

    Metastatic tumor research and outcomes network: a multicenter prospective registry for the management of metastatic spine tumors (MTRON)

    Charles Fisher

    NCT02830451

    Monitoring

    Primary tumor research and outcomes network: A multicenter prospective registry for the management of primary tumors of the spine (PTRON)

    Charles Fisher

    NCT02790983

    Monitoring

    Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK-1)

    Lawrence Lenke

    NCT01305343

    Publication

    Evaluation of neurologic complications associated with surgical correction of adult spinal deformity: 5-year follow-up extension (Scoli-RISK-1-extension)

    Lawrence Lenke

    NCT02949245

    Analysis

    Spine registry to collect outcome measures related to the disease status of patients with dpine disorders (DegenPRO)

    Tim Yoon

    NCT02802033

    Monitoring

    Thoracolumbar burst fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment (Spine_TL-A3-A4)

    Marcel Dvorak

    NCT02827214

    Monitoring

    Prognostic factors and therapeutic effects of surgical treatment for traumatic spinal column iInjury with spinal cord injury (SCI POEM)

    Allard Hosman

    NCT01674764

    Analysis

    C-Classification

    Alex Vaccaro

    n/a

    Analysis

  • AO CMF

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    An international, multicenter, prospective registry to collect data of treatment patterns of patients with Medication-Related OsteoNecrosis of the Jaw (MRONJ) and their outcome (MRONJ registry)

    Risto Kontion (University of Helsinki) and Sven Otto (Ludwig-Maximilian University, Munich)

    NCT02932501

    Monitoring

    International, multicenter, prospective registry to collect data of treatment patterns in patients with bilateral condylar fracture (BCFx) of the mandible (BCFx registry)

    Risto Kontio (University of Helsinki) and Edward Ellis 3rd (University of Texas Health Science Center at San Antonio)

    NCT02884765

    Monitoring

    A Multicenter Randomized Controlled Clinical Investigation to Investigate the Treatment of Double (Bilateral) Mandibular Fractures (DMFx)

    Risto Kontio and Edward Ellis 3rd

    NCT02341443

    Publication

    Orbita 3 - Additional publication

     

    n/a

    Publication

    International, multicenter, prospective registry to collect data on orbital fractures (OFx), their treatment and outcome

    Eppo B. Wolvius

    NCT03887988

    Monitoring

    International, multicenter, prospective registry to collect data in patients > 60 years suffering from mandibular fractures (MFx 60+)

    Risto Kontio

    NCT03849898

    Monitoring

    International, multicenter, prospective registry to collect data of patients treated with alloplastic temporomandibular joint (TMJ) replacements

    Andreas Thor

    NCT03991728

    Monitoring

     

  • AO Technical Commission

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    Evaluation of a growth guiding construct vs. standard dual growing rods and VEPTR for the treatment of early onset scoliosis patients: A prospective multi-center cohort study with a matched historical control. (TROLLEY)
     
    Jean Ouellet, MD, FRCSC
    NCT01672749
    Monitoring
    A focused registry on the conservative treatment of osteoarthritis of the knee (FR Tomofix) 
    Takeshi Sawaguchi
    NCT02077647
    Publication

    OpenGo Sensor Insole in open wedge HTO (Moticon - HTO)

    Stefan Döbele, Steffen Schröter

    NCT03222921

    Monitoring

    A prospective study to investigate postoperative real life weight bearing measured in patients treated with a Trochanter Fixation Nail Advanced (TFNA weight bearing)

    Michael Blauth, Karl Stoffel

    NCT03160508

    Monitoring

    A prospective multicenter observational registry for children up to 16 years of age with femur shaft fractures (PedFemFx)

    Peter Schmittenbecher, Unni Narayanan

    NCT03211546

    Monitoring

    A prospective case series study to monitor healing progression and real life weight bearing after tibial fracture using smart biofeedback systems (SmartFix II - Moticon) 

    Stefan Döbele

    NCT03166267

    Monitoring

    A focused registry on the Femoral Neck System (FNS) in patients with femoral neck fractures (FR FNS)

    Karl Stoffel

    NCT02422355

    Monitoring

    A randomized multicenter study comparing the effectiveness of hemi versus total shoulder arthroplasty in patients with a degenerative joint disease (EPOCA)

    Norbert Suedkamp

    NCT01288066

    Monitoring

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty (PPFx Registry)

    Karl Stoffel

    NCT03378557

    Monitoring

    Prospective multicenter registry for use of the MAXFRAMETM Multiaxial Correction System (MAXFRAME)

    Teddy Slongo

    NCT04017065

    Planning

    Locking plates for distal femur fractures – a multicenter case review
    A retrospective radiological analysis of the mechanical performance of different locking plates in distal femoral fractures (VA-LCP Case review) 

    Mark Lee

    n/a

    Monitoring

    An international, multicenter, prospective registry to investigate treatment options and their outcomes on Long Bones Defects (LoBoDeRe)

    Christoph Pape

    NCT04112992

    Planning

    Fracture-Related Outcome Study for operatively treated Tibia shaft fractures (FROST)

    Willem-Jan Metsemakers

    NCT03598530

    Monitoring

    Multicenter registry on indications, safety and clinical outcome of internal univector and curvilinear distraction devices in the treatment of congenital and acquired deformities of the craniomaxillofacial (CMF) skeleton (CMF distractor).

    Richard A. Hopper
    TBD Idea
    International, multicenter, prospective registry to collect data on treatment, outcome, and complications subsequent to reconstruction of acquired segmental mandibular defects in oral squamous cell carcinoma patients - SMDR (Segmental Mandibular Defect Reconstruction) registry
     
    Rüdiger M. Zimmerer
    NCT04098146
    Planning
    An International, Multicenter, Focused Registry to collect clinical data on the MatrixWAVE Mandibulo-Maxillary Fixation System (MatrixWAVE)
     
    Carl-Peter Cornelius
    NCT03405389
    Monitoring
    International, multicenter, prospective registry on 
    Patient-Specific Orthognathic Solutions (PSOS)
     
    Daniel Buchbinder
    TBD
    Idea

     

  • AO Education Institute

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    Development of performance metrics for cephalomedullary nailing for unstable pertrochanteric fractures- phase 1 (Immpact)

    Anthony Gallagher

    TBD

    Montoring

     

  • AO Development Incubator

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    Retrospective data collection in patients treated with immobilization of the metacarpals and/or phalanges of the hand with external fixation with K-wires and the fixation block "K-Blocks" (K-Blocks)

    Karl Heinz Bürger

    TBD

    Planning

    Prospective case series to analyze safety data in femoral and proximal tibial fracture patients treated with a locking compression plate with an attached investigational Fracture Monitor (Fracture Monitor-Femur/Proximal Tibia)

    Bendikt Braun

    TBD

    Planning


  • Collaboration with the AO Research Institute Davos (ARI)

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    A prospective case series study to monitor healing progression and real life wieght bearing after tibial fracture using smart biofeedback systems (Moticon SmartFix II)

    Stefan Döbele

    NCT03166267

    Monitoring

    Next generation SmartFix-integration with implants (SmartPlate)

    n/a

    n/a

    Idea



Find out more

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Innovation Translation

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Clinical Science

Clinical evidence generated through AO clinical studies can be accessed in the form of journal articles, presentations at scientific meetings, final study reports, guidelines, classifications, and/or news on the AO website.

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