Fracture-related infection and diabetes testing an antimicrobial

AO Trauma
Siverino C, Moriarty TFS, Thompson K, Zeiter S 

Background

Fracture-related infection (FRI) remains a challenging complication that creates a heavy burden for orthopedic trauma patients. Moreover, diabetes and obesity are two of the greatest risk factors for developing FRI. Several reports have examined the connection between increased risk of infection in diabetic patients. The underlying causes of increased susceptibility to infection in diabetic patients is not fully understood. 

 

5 mm humerus defect model in rabbit. Model already established for the Mascot project.

 

Goal

Establish a diabetic rabbit model and afterwards a diabetic rabbit model with FRI. Design and investigate new approaches to enhance fracture healing while clearing the infection in a FRI diabetic rabbit model.

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