Fracture-related infection and diabetes: testing an antimicrobial and osteoinductive functionalized scaffold in a new rabbit model (Sugar-FRI)

Background

Fracture-related infection (FRI) remains a challenging complication that creates a heavy burden for orthopedic trauma patients. Moreover, diabetes and obesity are two of the greatest risk factors for developing FRI. Several reports have examined the connection between increased risk of infection in diabetic patients. The underlying causes of increased susceptibility to infection in diabetic patients is not fully understood. 

 

 

Goal

Establish a diabetic rabbit model and afterwards a diabetic rabbit model with FRI. Design and investigate new approaches to enhance fracture healing while clearing the infection in a FRI diabetic rabbit model.

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