Development of 3 dimensional in vitro models of bone infection (Immunobact)

Background

Staphylococcus aureus is a prominent pathogen in bone-related infections where it can form staphylococcal abscess communities (SACs). SACs are a dense population of S. aureus within a fibrin pseudocapsule and are implicated in fracture related infection. 

 

 

Goal

To establish an in vitro SAC model that resembles in vivo SACs. 


  • Publication

    Hofstee MI, Riool M, Terjajevs I, Thompson K, Stoddart MJ, Richards RG, Zaat SAJ, Moriarty TF. 3-dimensional in vitro Staphylococcus aureus abscess communities display antibiotic tolerance and protection from neutrophil clearance. Infect Immun. 2020;epub Aug 17

    Hofstee MI, Muthukrishnan G, Atkins GJ, Riool M, Thompson K, Morgenstern M, Stoddart MJ, Richards RG, Zaat SAJ, Moriarty TF. Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods. Am J Pathol. 2020 Jun;190(6):1151-1163.

     

     

  • Presentation

    Hofstee M, Riool M, Thompson K, Zaat SAJ, Stoddart MJ, Richards RG, Moriarty TJ. "A novel 3-dimensional in vitro model for Staphylococcus aureus abscess communities", Maastricht, the Netherlands, 2-4 October 2019 (oral)

    Hofstee M, Riool M, Thompson K, Zaat SAJ, Stoddart MJ, Richards RG, Moriarty TF. "A novel 3-dimensional in vitro model for Staphylococcus aureus abscess communities", Davos, Switzerland, 26-28 June 2019 (poster)

    Hofstee M, Riool M, Thompson K, Zaat SAJ, Stoddart MJ, Richards RG, Moriarty TF. "A novel 3-dimensional multicellular in vitro model for Staphylococcus aureus microcolony interaction with neutrophils.", Davos, Switzerland, 6-9 April 2019 (poster)

  • Partner

    SAJ Zaat (MD), Amsterdam UMC, Amsterdam, the Netherlands

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