Fracture related infections (FRI) can be a serious outcome for orthopedic trauma patients. FRI leads to longer treatment times, and sometimes permanent disability or loss of limbs. The FRIs are directly translated into increased health care costs. Treatment options for FRI include debridement, irrigation and implant retention (DAIR) in combination with systemic antibiotics, implant exchange or others. In many instances the delivery of the antibiotics can be compromised due to damage in the vascular system, or the antibiotics do not reach a therapeutically effective concentration in the affected area.
PublicationD'Este, Non-stick Antibiotic Gels, WO2021122278