3D sound induced morphogenesis (3D-SIM)



Throughout the BRIDGE funding period, a novel 3D cell technology, named 3D Sound Induced Morphogenesis (3D-SIM) was developed. More specifically, the generation of a first 3D-SIM prototype to be: 1/ easily implemented into laboratory environment (small, portable, suitable for sterile setting), 2/ affordable and user friendly, and 3/ able to create 3D cell models in a time effective manner, with sufficient spatial complexity, retaining cell viability was achieved. Finally, functionality evaluation of 3D-SIM tech was done through a proof of concept in vitro cell model: a 3D vascularized construct. The patent: "Surface Acoustic Wave (SAW) 3D-Printing Method", filed in August 2017, was further improved with detailed data from BRIDGE project and submitted to the international patent application (PCT) published in February 2019. Moreover, to get more visibility, both in the industrial and academic environment, outcomes from the project have been presented in different international conferences such as the TERMIS-EU in Rhodes, the European Society of Biomaterials in Maastricht, the International Society of Biofabrication in Wurzburg where the first prize for outstanding achievements in the field of biofabrication and 3D cell assembly was given to the project. A start-up company, named MimiX Biotherapeutics Ltd was created in Autumn 2019. 


BRIDGE (nr 20B1-1_178259) CHF 130'000, Period: 2018-2019.

  • Publication

    Petta D, Basoli V, Pellicciotta D, Tognato R, Barcik JP, Arrigoni C, Della Bella E, Armiento AR, Candrian C, Richards RG, Alini M, Moretti M, Eglin D, Serra T. Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks. Biofabrication. 2020 Sep 25.

  • Presentation

    Pellicciotta D, Richards RG, Eglin D, Alini M, Serra T. A sound-induced technology for multiscale organization of perfusable micro-vessels networks TERMIS EU, Rhodos, 2019, p. 1358 / 819 (eCM coll).

    Serra T, Pellicciotta D, Basoli V, Della Bella E, Armiento AR, Richards RG, Alini M, Eglin D. Spatially orchestrated micro-vessels networks via acoustic waves cell patterning, SSB+RM Swiss Conference on Biomaterials and Regenerative Medicine eCM Periodical: Abstract Collections Muttenz, 2019, p. 10.

    Serra T. A sound-induced technology for multiscale orchestration of functional vessels networks, ATSM 1st Advanced Therapies Science Meeting, Berlin, 2019.

    Serra T. A sound-induced technology for multiscale organization of perfusable micro-vessels networks, EMBL Symposium: Synthetic Morphogenesis, Heidelberg, 2019.


  • Partner

    Moretti M (PhD), Swiss Institute for Regenerative Medicine, Switzerland

    de Bruijn J (Prof), Kuros Biosciences, Switzerland

    Millan C (PhD), CellSpring, Switzerland

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