Infection studies

Understanding the pathogenesis of musculoskeletal infection and developing customized interventions

In vitro testing

  • Antimicrobial efficacy testing of anti-infective surfaces
  • Bacterial adhesion and biofilm formation on test materials
  • Imaging of test surfaces with or without bacteria/biofilm using Scanning Electron Microscopy (SEM)
  • Biobank of clinical bacterial isolates from patients with bone and implant infection

 

Animal models

  • Mouse, rat, rabbit, and sheep models of infection prevention
  • Rat, rabbit, and sheep models of infection treatment
  • Experience in working with antibiotic resistant pathogens (eg, MRSA)
  • Systemic and local application of antibiotics/antimicrobials histological preparation
  • Histological analysis of infected tissues with bacteria-specific staining

 

Analysis

  • Determining antimicrobial efficacy of specific devices or biomaterials
  • Quantitative bacteriological analysis of biological specimens including bone
  • Quantitative analysis of explanted hardware

In vivo models of infection at ARI, l-r: mouse femoral plate, rabbit humeral nail, rabbit humeral LCP, rat tibial screw, sheep tibial nail

Intraoperative image showing fixation of the humerus with an LCP in our rabbit model of fracture-related infection

False colored scanning electron micrograph of a biofilm formed by Staphylococcus aureus on implant surface, showing fibrin formation in red

Qualifications

  • Microbiologists (PhDs) experienced in infection studies
  • PhD level scientists and experienced project leaders
  • Highly qualified technicians

Certification

  • ISO 9001:2015
  • Good Laboratory Practice (GLP)

Contact

Ulrich Bentz

AO Research Institute Davos

Clavadelerstrasse 8

7270 Davos Platz

Switzerland

Tel.: +41 81 414 23 26

www.aofoundation.org/crd

 

Send e-mail >

Preclinical surgery

Biomechanical testing and modelling

Medical imaging

Histology, tissue morphology and microscopy

Tissue engineering and cell biology

Meet the team

Learn more about the staff of the AO Research Institute.

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