Histology, tissue morphology and microscopy

Highly-skilled tissue processing, imaging, and analysis

Study design

  • Assistance in project planning and experimental set-up based on scientific question
  • Evaluation of samples, photodocumentation, and report writing


Histological preparation and techniques

  • Undecalcified bone histology with or without implants (eg, metal, calcium phosphates, polymers)
  • Sectioning of resin embedded samples with specialty equipment
  • Contact radiography
  • Decalcification of tissues
  • Paraffin embedding and sectioning
  • Cryosectioning
  • Immunohistochemistry (with protocol planning)
  • Routine to special stains (for resin and non-resin embedded samples)


Microscopy and image analysis

  • Brightfield light microscopy for sections with or without implants
  • Epifluorescent microscopy for fluorochrome labelled sections (eg, bone labels, marked antibodies)
  • Macrophotography for overview images of larger samples
  • Confocal laser microscopy for optical sectioning
  • Scanning electron microscope equipped with Energy Dispersive X-Ray Spectroscopy (EDX or EDS)
  • White light profilometry for surface characterization (eg, roughness values)
  • Quantitative analysis (eg, lengths, areas, numbers) on histological samples

CD31 immunohistochemical stain showing a blood vessel, of a decalcified, cryosectioned coracoclavicular ligament

Safranin O/Fast Green staining: resin embedded sheep lumbar disc


  • Certified vet. pathologist


  • ISO 9001
  • Good Laboratory Practice (GLP)


Ulrich Bentz

AO Research Institute Davos

Clavadelerstrasse 8

7270 Davos Platz


Tel.: +41 81 414 23 26



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Preclinical surgery

Biomechanical testing and modelling

Medical imaging

Tissue engineering and cell biology

Infection studies

Meet the team

Learn more about the staff of the AO Research Institute.

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