Call for pre-proposals: AO Trauma Clinical Priority Program Fracture Non-union
Deadline for application: April 23, 2023
The AO Trauma Research Commission launches the following open consortium call (pre-proposals).
The AO Trauma Research Commission (AO TRC) has allocated funds for research programs designed to address important clinical problems. Beginning 2024, AO TRC will launch a program to study fracture non-union for a period of 5 years. The AO Trauma Research Commission (AO TRC) is pleased to announce a call for consortia in the field of 'Fracture Non-union'. The application is a two-stage process.
Despite substantial advances in orthopaedic trauma surgery, a subset of patients still suffers from fracture healing complications, resulting in delayed union and non-union. A variety of potential factors may be involved, amongst which mechanical stability, biological environment and infection are the most important. It is now appreciated that delayed healing and non-union may also result from low virulence bacterial infections that are challenging to detect. There is, therefore, a great need to further study the different underlying mechanisms leading to fracture non-union both from infectious and non-infectious origins.
This new AO Trauma Clinical Priority Program (CPP) builds on the highly successful AO Trauma CPP Fracture Related Infection (FRI) and addresses non-union as a closely related topic. The existing AO Trauma CPP FRI has provided important scientific and clinical knowledge that can serve as a roadmap for the new AO Trauma CPP. The AO Trauma CPP Fracture non-union should aim to further improve patient care and identify mechanisms of and solutions for infectious and non-infectious fracture healing problems.
Research topics of the new AO Trauma CPP Fracture non-union may include (but is not limited to)
- Differential diagnosis of FRI from aseptic non-union
- Underlying biological processes of fracture non-union
- Underlying mechanical factors leading to non-union
- Underlying infectious factors leading to non-union
- Clinical registries of infectious and non-infectious non-union
- Emerging therapies for non-union that are ready for translational studies
- Translation of research on FRI related non-union towards clinical application
Elements of the call
Each application should:
- be part of an international consortium and apply for the entire funding amount
- be interconnected or interdisciplinary projects, spanning over a period of 5 years
- include projects covering infection-related fracture non-union
- include projects covering non-infectious related fracture non-union
- include basic research and/or translational and/or clinical studies
- include collaboration with the AO Research Institute (ARI) Davos
- include collaboration with the AO Innovation Translation Center (ITC), Clinical Science
- include travel expenses to annual AO Trauma CPP meetings
The total amount of funding for external projects is expected to be CHF 2,15mio for 5 years (CHF 430k per year). ARI and AO ITC are not included within this total amount, as they have their own funds (ear-marked budget to AO Trauma).
As outlined in the guideline document:
Review and approval
The full proposal applications will be peer-reviewed by the AO Foundation Research Review Commission (AO RRC) and final approved by the AO TRC.
Process of call and approval of consortium
- Launch call for pre-proposals: February 16, 2023
- Deadline for pre-proposals: April 23, 2023
- Review and selection for full-proposals by AO TRC: June 2023
- Deadline for selected full-proposals: August 2023
- AO RRC peer-review: August 2023 – December 2023
- Final decision by AO TRC: February 2024