Clinical Priority Program Bone Infection

To achieve a better understanding of bone infection, provide solutions for this very pressing clinical problem and have a positive impact on patient care.

The pillars of the Clinical Priority Program Bone Infection

Host-pathogen interaction

Learn about how S. aureus adapts to the environment of an implant-associated infection.


Read about the development of new tools to assess implant-associated infections.


Explore how the CPP Bone Infection is running its surgical site prevention program.

Prophylaxis and treatment

Learn about treatment and prevention of implant-associated infections.


Explore the educational program of the CPP Bone Infection.


Read about the first international bone infection registry.

Bone Infection as an AO Trauma Clinical Priority Program (CPP)

Trauma surgeons have long recognized infections as one of the most serious and distressing complications of operative fracture care. While the incidence of fracture-related infection (FRI) is relatively low in closed fractures, the risk increases dramatically for open fractures, with an estimated 27 percent incidence in civilians and 40 percent in war injuries. However, surgical treatment options are often complicated by the need for fracture stability and implant removal.

Despite best current practice including antibiotic prophylaxis, we have failed to eliminate costly bone infection. The increasing prevalence of drug-resistant pathogens signals a new obstacle. Furthermore, despite elaborate revision protocols, treatment failure rates can be as high as 50 percent, leading to loss of function, arthrodesis, amputation, and death. Therefore, infection has made a serious resurgence as a major complication of orthopedic trauma and reconstruction surgery. As we approach the limit of the effectiveness of current techniques, novel approaches to infection management must be developed.

“The projects within the CPP have been expansive and ambitious from the outset. Trauma’s CPP has the potential to change the way clinicians think about bone infection, with projects aimed specifically at prevention, diagnosis, treatment, documentation, and education.”

Stephen Kates, Virginia Commonwealth University, Richmond, USA


Check the publications of the CPP Bone Infection

You might also be interested in:


Download the CPP Bone Infection meeting flyers.


Meet the international team of the CPP Bone Infection.


Read about the awards of the CPP Bone Infection team.

Connect with us

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