Tissue engineering and cell biology

Developing novel trauma repair treatments within the musculoskeletal system

Cell and tissue culture

  • Cell isolation (eg, osteoblasts, chondrocytes, stem cells) from various tissues (eg, bone, cartilage, disc, veins, bone marrow, peripheral blood) and from various species (eg, human samples, bovine, sheep, rat)
  • Tissue biopsies from various locations and species (eg, cartilage and intervertebral disc)
  • Two-dimensional and threedimensional cell culture
  • Differentiation of precursor or stem cells in specific cell types (eg, osteoblasts or chondrocytes)
  • Bioreactor culture systems for intervertebral disc (organ culture) and articular cartilage (pin-on-ball)
  • Gene transfer: non-viral and viral



  • Gene expression
  • Isotope incorporation
  • Biochemical analysis (eg, glycosaminoglycan, DNA, alkaline phosphatase)
  • Cell viability
  • Time lapse microscopy
  • Protein analysis
  • Fluorescence Activated Cell Sorting
  • Biomarker screening


Polymer Processing and Characterization

  • 3-D Printing, biofabrication, scaffold, film and membrane processing
  • Gel permeation chromatography, viscosimetry, thermal analysis, trace analysis, in vitro degradation, contact angle, hydrolytic permeability, rheology

Cartilage bioreactor for cell-seeded scaffolds and osteochondral explants

3D printed bioink


  • Experienced scientists (PhD) supervise studies
  • Multidisciplinary team (biologists, chemists, engineers, medical fellows)
  • Highly qualified technicians with up to 25 years experience


  • ISO 9001


Ulrich Bentz

AO Research Institute Davos

Clavadelerstrasse 8

7270 Davos Platz


Tel.: +41 81 414 23 26



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Preclinical surgery

Biomechanical testing and modelling

Medical imaging

Histology, tissue morphology and microscopy

Infection studies

Meet the team

Learn more about the staff of the AO Research Institute.

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