AO Spine Knowledge Forum Deformity

Creating a common language and framework for researchers and clinicians

Goals

AO Spine KF Deformity at the Global Spine Congress 2022 in Las Vegas

AO Spine KF Deformity aims to improve the care for patients with a spinal deformity by generating and disseminating meaningful and impactful clinical evidence.

They do this by engaging leading clinicians, researchers, and spine centers from around the world to perform evidence-based research and by disseminating the research findings and newfound knowledge through publications and presentations.

Ongoing research projects

  • AO Spine Knowledge Forum Deformity Focus Issue

    Principal investigator:

    Stephen Lewis

    Co-Principal investigators:

    Lawrence Lenke

    Goals:

    Aims to provide a thorough review of the current status of adult spinal deformity surgery and highlight areas of controversy. The issue will provide guidance through the current literature and help identify future directions to help answer some of the difficulties encountered in treating this complex and highly variable disorder.

  • */** Spinal Deformity Intraoperative Monitoring (SDIM)

    Principal investigator:

    Stephen Lewis

    Co-Principal investigators:

    Lawrence Lenke, Nasir Quraishi

    Goals:

    Aims to determine the incidence of intraoperative neuromonitoring alerts in complex, high-risk, spinal deformity surgeries and identify the events that lead to such alerts

    Remark:

    This project was awarded with a Standard Research Grant (2018) from the Scoliosis Research Society (SRS).

    Documents:

    Publication summary

    ClinicalTrials.gov Identifier: NCT03880292

  • Complication Classification System of Spinal Deformity Surgery (CCS-SDS)

    Principal investigator:

    Sigurd Berven

    Co-Principal investigators:

    Lawrence Lenke, Christopher Shaffrey

    Goals:

    Aims to develop and validate a reliable system for categorizing and classifying various complications during and following adult spinal deformity surgery

  • * Prospective Evaluation of Elderly Deformity Surgery (PEEDS): five-year extension

    A prospective observational, multicenter study

    Principal investigator:

    Stephen Lewis

    Co-Principal investigators:

    Sigurd Berven

    Goals:

    Aims to show an improvement in SRS-22 total score between baseline and 24 months and five years after surgery in patients at age 60 or older treated with major spinal reconstruction (spinal fusion of at least five levels) for adult spinal deformity

    Documents:

    Publication summary

    ClinicalTrials.gov Identifier: NCT02035280

  • Peri-Operative Management (POMa) spine survey

    Principal investigator:

    Dr. Stephen J. Lewis, MD

    Co-Principal investigator:

    Dr. So Kato, MD

    Goal:

    To understand the current trends in peri-operative ASD surgery management based on an international survey


  • SMART - Durability of supplementary rod constructs—SuppleMentAry Rod Technique (SMART)—for long-segment posterior instrumented spinal fusion procedures: A multicenter retrospective comparative study with dual-rod constructs

    Principal investigator:

    Dr. Justin S. Smith, MD, PhD

    Co-Principal investigators:

    Dr. Stephen J. Lewis, MD
    Dr. Michael P. Kelly, MD

    Goal:

    To compare rod fracture rates after index surgery between patients having received supplementary rod constructs and patients having received dual-rod constructs

Completed research projects

  • */** Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK 1)

    A prospective, observational, multi-center study

    Principal investigator:

    Lawrence Lenke

    Co-Principal investigators:

    Michael Fehlings

    Goals:

    Aim was to establish the risk of neurologic deficit related to surgical correction of adult spinal deformity and to identify characteristics associated with increased risk of neurologic complications related to the surgery

    Remark:

    This project received co-funding from the Scoliosis Research Society (SRS) and Norton Healthcare

    Documents:

    Publication summary

    ClinicalTrials.gov Identifier: NCT01305343

  • FLEXIbility in Scoliosis (FLEXIS)

    Comparison of dynamic radiographs in determining fusion level in adolescent idiopathic scoliosis correction

    Principal investigator:

    Kenny Kwan

    Co-Principal investigators:

    Kenneth Cheung, Ahmet Alanay

    Goals:

    Aims to identify the dynamic radiograph(s) that can most accurately predict the curve behavior after surgical correction in patients diagnosed with adolescent idiopathic scoliosis

    Documents:

    Publication summary

    ClinicalTrials.gov Identifier: NCT03296228

  • Identification of a core outcome set for spinal deformity surgery (COSSCO)

    Core Outcome Set for SCOliosis (COSSCO)

    Principal investigator:

    Marinus de Kleuver

    Co-Principal investigators:

    David Polly

    Goals:

    Aim was to develop a core outcome set specific to spinal deformity that represents the minimum that should be measured and reported in all outcome registries of a specific condition

    Documents:

    Publication summary

  • An international consensus on the appropriate treatment for adults with spinal deformity (ASD Consensus)

    Principal investigator:

    Sigurd Berven

    Co-Principal investigators:

    Marinus de Kleuver

    Goals:

    Aim was to identify goals of care and management strategies that are appropriate for adult spinal deformity patients based upon worldwide expert opinion

    Documents:

    Publication summary

  • An international consensus on the surgical treatment standards for adolescent idiopathic scoliosis (AIS Consensus)

    Principal investigator:

    Marinus de Kleuver

    Co-Principal investigators:

    Manabu Ito

    Goals:

    Aim was to investigate what constitutes optimal operative care for adolescent idiopathic scoliosis patients between 12 and 20 years of age with curves ranging from 40 to 90 degrees Cobb angle

    Documents:

    Publication summary

  • AO Spine Comprehensive Classification of Adult Spinal Deformity (AOASD)

    Principal investigator:

    J Naresh-Babu

    Co-Principal investigators:

    Manabu Ito, Jong-Beom Park, Kenny Kwan

    Goals:

    Aims to develop comprehensive classification that separates patients into clinically different subgroups that require different treatment strategies

    Documents:

    AO Spine ASD Patient Profile

  • * Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK 1): five-year extension

    A prospective, observational, multi-center study

    Principal investigator:

    Lawrence Lenke

    Co-Principal investigators:

    Michael Fehlings

    Goals:

    Aims to establish the long-term risk of neurologic deficit related to the surgical correction of adult spinal deformity and to identify characteristics associated with an increased risk of neurologic complications related to surgery at five-year postoperative

    ClinicalTrials.gov Identifier: NCT02949245

* This AO Spine-sponsored study is executed with support from AO Clinical Investigation and Documentation (AO CID). 

** Award-winning project

KF Deformity Steering Committee

Stephen Lewis
Chairperson
Toronto Western Hospital
Toronto, Canada

Lawrence Lenke
Columbia University New York,
New York, USA

Sigurd Berven
University of California San Francisco
San Francisco, USA

Ahmet Alanay
Acibadem Mehmet Ali Aydinlar
University School of Medicine
Istanbul, Turkey

Yukihiro Matsuyama
Hamamatsu University School of Medicine
Hamamatsu, Japan

Michael Kelly
Washington University
St Louis, USA

Justin Smith
University of Virginia
Charlottesville, USA

Caglar Yilgor
Acibadem University Maslak Hospital
Istanbul, Turkey

Kenny Kwan
University of Hong Kong
Hong Kong

Ferran Pellise Urquiza
Hospital Vall d'Hebron / Barcelona Spine Institute Hospital Quiron
Barcelona, Spain

KF Advisory Board

Kenneth Cheung
The University of Hong Kong
Hong Kong, China

David Polly
University of Minnesota
Minneapolis, USA

Yong Qiu
Nanjing University
Nanjing, China

Christopher Shaffrey
Duke University Medical Center
Durham, USA

KF Deformity Associate Members

 

Christopher Ames, University of California San Diego, San Diego, CA, USA
Saumyajit Basu, Kothari Medical Center and Park Clinic, Kolkata, India
Anastasios Charalampidis, Karolinska University Hospital, Solna, Sweden
André Luis Fernandes Andújar, Hospital Infantil Joana de Gusmão, Florianópolis, Brazil
Munish Gupta, Washington University School of Medicine, St. Louis, MO, USA
So Kato, The University of Tokyo, Tokyo, Japan
Eric Klineberg, University of California, Davis, Sacramento, CA, USA 
Kenny Kwan, The University of Hong Kong, Hong Kong
Christopher Nielsen, Toronto Western Hospital, Toronto, Canada 
Ferran Pellisé, Spine Unit Vall d'Hebron, Barcelona, Spain
Zeeshan Sardar, Columbia University, New York, NY, USA 
Miranda van Hooff, Radboud University Medical Center/Sint Maartenskliniek, Nijmegen, Netherlands 
Yilgor Caglar, Acibadem Maslak Hospital, Istanbul, Turkey
Alekos Theologis, University of California San Francisco, San Francisco, CA, USA 
Anna Rienmueller, Medizinische Universität Wien, Wien Austria 
Brett Rocos, Duke University Medical Center, Durham, USA
Colby Oitment, McMaster University, Hamilton Ontario, Canada
Federico Landriel, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Swamy Ganesh, University of Calgary, Calgary, Canada
Yoshida Go, Hamamatsu University School of Medicine, Tokyo, Japan
Shen Jianxiong, Peking Union Medical College Hospital, Beijing, China
John Street, Vancouver General Hospital, Vancouver General Hospital, Canada
Juan Uribe, Barrow Neurological Institute, Phoenix AZ, USA
Kristen Jones, University of Minnesota, Minneapolis MN, USA
Thorsten Jentzsch, Balgrist Universitätsklinik, Zürich, Switzerland
Zhu Zezhang, Nanjing University Medical School, Nanjing, China
Jeffrey Hills, UT Health San Antonio, San Antonio, USA
Juan Sardi, University of Texas Southwestern Medical Center, Texas, USA
Elias Elias, University of Texas, Texas, USA
Jonathan Sembrano, University of Minnesota Medical School, Minnesota MN, USA
Aaron J. Buckland, Melbourne Orthopaedic Group Australia, Melbourne Australia

Knowledge Forum Manager

Janneke Loomans

Janneke Loomans

Project Manager

Other Knowledge Forums

AO Spine KF Tumor

AO Spine KF Spinal Cord Injury (SCI)

AO Spine KF Trauma

AO Spine KF Degenerative

“There is a myriad of outcome studies and instruments out there; everybody uses different tools to measure their quality of care. We help bring more rationale to the options that are available.”

Marinus de Kleuver, Past Chairperson KF Deformity