AO Spine Knowledge Forum Deformity

Creating a common language and framework for researchers and clinicians

Goals
Ongoing research projects
Completed research projects
Steering Committee
Other Knowledge Forums

Goals

AO Spine KF Deformity at the Global Spine Congress 2022 in Las Vegas

AO Spine KF Deformity aims to improve the care for patients with a spinal deformity by generating and disseminating meaningful and impactful clinical evidence.

They do this by engaging leading clinicians, researchers, and spine centers from around the world to perform evidence-based research and by disseminating the research findings and newfound knowledge through publications and presentations.

Ongoing research projects

AO Spine Knowledge Forum Deformity Focus Issue

Principal investigator:

Stephen Lewis

Co-Principal investigators:

Lawrence Lenke

Goals:

Aims to provide a thorough review of the current status of adult spinal deformity surgery and highlight areas of controversy. The issue will provide guidance through the current literature and help identify future directions to help answer some of the difficulties encountered in treating this complex and highly variable disorder.
Tension Parameters in Junctional Tethers for Proximal Junctional Kyphosis (PJK)

Principal investigator:

Tim O’Connor

Co-Principal investigators:

Mary O’Hehir, Jeffrey Mullin

Goals:

Aims to determine optimal tension parameters in junctional tethers for PJK
AO Spine Comprehensive Classification of Adult Spinal Deformity (AOASD)

Principal investigator:

J Naresh-Babu

Co-Principal investigators:

Manabu Ito, Jong-Beom Park, Kenny Kwan

Goals:

Aims to develop comprehensive classification that separates patients into clinically different subgroups that require different treatment strategies

Documents:

AO Spine ASD Patient Profile
*/** Spinal Deformity Intraoperative Monitoring (SDIM)

Principal investigator:
Stephen Lewis
Co-Principal investigators:
Lawrence Lenke, Nasir Quraishi
Goals:
Aims to determine the incidence of intraoperative neuromonitoring alerts in complex, high-risk, spinal deformity surgeries and identify the events that lead to such alerts
Remark:
This project was awarded with a Standard Research Grant (2018) from the Scoliosis Research Society (SRS).
Documents:
Publication summary
ClinicalTrials.gov Identifier: NCT03880292
Complication Classification System of Spinal Deformity Surgery (CCS-SDS)

Principal investigator:

Sigurd Berven

Co-Principal investigators:

Lawrence Lenke, Christopher Shaffrey

Goals:

Aims to develop and validate a reliable system for categorizing and classifying various complications during and following adult spinal deformity surgery
* Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK 1): five-year extension

A prospective, observational, multi-center study

Principal investigator:

Lawrence Lenke

Co-Principal investigators:

Michael Fehlings

Goals:

Aims to establish the long-term risk of neurologic deficit related to the surgical correction of adult spinal deformity and to identify characteristics associated with an increased risk of neurologic complications related to surgery at five-year postoperative

ClinicalTrials.gov Identifier: NCT02949245
* Prospective Evaluation of Elderly Deformity Surgery (PEEDS): five-year extension

A prospective observational, multicenter study

Principal investigator:

Stephen Lewis

Co-Principal investigators:

Sigurd Berven

Goals:

Aims to show an improvement in SRS-22 total score between baseline and 24 months and five years after surgery in patients at age 60 or older treated with major spinal reconstruction (spinal fusion of at least five levels) for adult spinal deformity

Documents:

Publication summary

ClinicalTrials.gov Identifier: NCT02035280

* This AO Spine-sponsored study is executed with support from the AO Innovation Translation Center (AO ITC).

** Award-winning project

Completed research projects

*/** Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK 1)

A prospective, observational, multi-center study

Principal investigator:

Lawrence Lenke

Co-Principal investigators:

Michael Fehlings

Goals:

Aim was to establish the risk of neurologic deficit related to surgical correction of adult spinal deformity and to identify characteristics associated with increased risk of neurologic complications related to the surgery

Remark:

This project received co-funding from the Scoliosis Research Society (SRS) and Norton Healthcare

Documents:

Publication summary

ClinicalTrials.gov Identifier: NCT01305343
FLEXIbility in Scoliosis (FLEXIS)

Comparison of dynamic radiographs in determining fusion level in adolescent idiopathic scoliosis correction

Principal investigator:

Kenny Kwan

Co-Principal investigators:

Kenneth Cheung, Ahmet Alanay

Goals:

Aims to identify the dynamic radiograph(s) that can most accurately predict the curve behavior after surgical correction in patients diagnosed with adolescent idiopathic scoliosis

Documents:

Publication summary

ClinicalTrials.gov Identifier: NCT03296228
Identification of a core outcome set for spinal deformity surgery (COSSCO)

Core Outcome Set for SCOliosis (COSSCO)

Principal investigator:

Marinus de Kleuver

Co-Principal investigators:

David Polly

Goals:

Aim was to develop a core outcome set specific to spinal deformity that represents the minimum that should be measured and reported in all outcome registries of a specific condition

Documents:

Publication summary
An international consensus on the appropriate treatment for adults with spinal deformity (ASD Consensus)

Principal investigator:

Sigurd Berven

Co-Principal investigators:

Marinus de Kleuver

Goals:

Aim was to identify goals of care and management strategies that are appropriate for adult spinal deformity patients based upon worldwide expert opinion

Documents:

Publication summary
An international consensus on the surgical treatment standards for adolescent idiopathic scoliosis (AIS Consensus)

Principal investigator:

Marinus de Kleuver

Co-Principal investigators:

Manabu Ito

Goals:

Aim was to investigate what constitutes optimal operative care for adolescent idiopathic scoliosis patients between 12 and 20 years of age with curves ranging from 40 to 90 degrees Cobb angle

Documents:

Publication summary

* This AO Spine-sponsored study is executed with support from AO Clinical Investigation and Documentation (AO CID).

** Award-winning project

KF Deformity Steering Committee

KF Advisory Board

KF Deformity Associate Members

Christopher Ames, University of California San Diego, San Diego, CA, USA
Saumyajit Basu, Kothari Medical Center and Park Clinic, Kolkata, India
Anastasios Charalampidis, Karolinska University Hospital, Solna, Sweden
André Luis Fernandes Andújar, Hospital Infantil Joana de Gusmão, Florianópolis, Brazil
Munish Gupta, Washington University School of Medicine, St. Louis, MO, USA
So Kato, The University of Tokyo, Tokyo, Japan
Eric Klineberg, University of California, Davis, Sacramento, CA, USA
Kenny Kwan, The University of Hong Kong, Hong Kong
Venugopal (KV) Menon, Sparsh Hospital, Karnataka, India
J Naresh-Babu, Mallika Spine Center, Guntur, Andhra Pradesh, India
Christopher Nielsen, Toronto Western Hospital, Toronto, Canada
Tim O’Connor, University at Buffalo Neurosurgery, Buffalo, NY, USA
Ferran Pellisé, Spine Unit Vall d'Hebron, Barcelona, Spain
Zeeshan Sardar, Columbia University, New York, NY, USA
Miranda van Hooff, Radboud University Medical Center, Nijmegen, Netherlands
Emiliano Vialle, Cajuru University Hospital, Catholic University of Parana, Curitiba, Brazil
Caglar Yilgor, Acibadem Maslak Hospital, Istanbul, Turkey

Knowledge Forum Manager

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