AO Spine Knowledge Forum Deformity

Creating a common language and framework for researchers and clinicians

Goals
Ongoing research projects
Completed research projects
Steering Committee
Other Knowledge Forums

Goals

AO Spine KF Deformity at the Global Spine Congress 2022 in Las Vegas

AO Spine KF Deformity aims to improve the care for patients with a spinal deformity by generating and disseminating meaningful and impactful clinical evidence.

They do this by engaging leading clinicians, researchers, and spine centers from around the world to perform evidence-based research and by disseminating the research findings and newfound knowledge through publications and presentations.

Ongoing research projects

AO Spine Knowledge Forum Deformity Focus Issue

Principal investigator:

Stephen Lewis

Co-Principal investigators:

Lawrence Lenke

Goals:

Aims to provide a thorough review of the current status of adult spinal deformity surgery and highlight areas of controversy. The issue will provide guidance through the current literature and help identify future directions to help answer some of the difficulties encountered in treating this complex and highly variable disorder.
*/** Spinal Deformity Intraoperative Monitoring (SDIM)

Principal investigator:

Stephen Lewis

Co-Principal investigators:

Lawrence Lenke, Nasir Quraishi

Goals:

Aims to determine the incidence of intraoperative neuromonitoring alerts in complex, high-risk, spinal deformity surgeries and identify the events that lead to such alerts

Remark:

This project was awarded with a Standard Research Grant (2018) from the Scoliosis Research Society (SRS).

Documents:

Publication summary

ClinicalTrials.gov Identifier: NCT03880292
Complication Classification System of Spinal Deformity Surgery (CCS-SDS)

Principal investigator:

Sigurd Berven

Co-Principal investigators:

Lawrence Lenke, Christopher Shaffrey

Goals:

Aims to develop and validate a reliable system for categorizing and classifying various complications during and following adult spinal deformity surgery
* Prospective Evaluation of Elderly Deformity Surgery (PEEDS): five-year extension

A prospective observational, multicenter study

Principal investigator:

Stephen Lewis

Co-Principal investigators:

Sigurd Berven

Goals:

Aims to show an improvement in SRS-22 total score between baseline and 24 months and five years after surgery in patients at age 60 or older treated with major spinal reconstruction (spinal fusion of at least five levels) for adult spinal deformity

Documents:

Publication summary

ClinicalTrials.gov Identifier: NCT02035280
Peri-Operative Management (POMa) spine survey

Principal investigator:

Dr. Stephen J. Lewis, MD

Co-Principal investigator:

Dr. So Kato, MD

Goal:

To understand the current trends in peri-operative ASD surgery management based on an international survey
SMART - Durability of supplementary rod constructs—SuppleMentAry Rod Technique (SMART)—for long-segment posterior instrumented spinal fusion procedures: A multicenter retrospective comparative study with dual-rod constructs

Principal investigator:

Dr. Justin S. Smith, MD, PhD

Co-Principal investigators:

Dr. Stephen J. Lewis, MD
Dr. Michael P. Kelly, MD

Goal:

To compare rod fracture rates after index surgery between patients having received supplementary rod constructs and patients having received dual-rod constructs

Completed research projects

*/** Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK 1)

A prospective, observational, multi-center study

Principal investigator:

Lawrence Lenke

Co-Principal investigators:

Michael Fehlings

Goals:

Aim was to establish the risk of neurologic deficit related to surgical correction of adult spinal deformity and to identify characteristics associated with increased risk of neurologic complications related to the surgery

Remark:

This project received co-funding from the Scoliosis Research Society (SRS) and Norton Healthcare

Documents:

Publication summary

ClinicalTrials.gov Identifier: NCT01305343
FLEXIbility in Scoliosis (FLEXIS)

Comparison of dynamic radiographs in determining fusion level in adolescent idiopathic scoliosis correction

Principal investigator:

Kenny Kwan

Co-Principal investigators:

Kenneth Cheung, Ahmet Alanay

Goals:

Aims to identify the dynamic radiograph(s) that can most accurately predict the curve behavior after surgical correction in patients diagnosed with adolescent idiopathic scoliosis

Documents:

Publication summary

ClinicalTrials.gov Identifier: NCT03296228
Identification of a core outcome set for spinal deformity surgery (COSSCO)

Core Outcome Set for SCOliosis (COSSCO)

Principal investigator:

Marinus de Kleuver

Co-Principal investigators:

David Polly

Goals:

Aim was to develop a core outcome set specific to spinal deformity that represents the minimum that should be measured and reported in all outcome registries of a specific condition

Documents:

Publication summary
An international consensus on the appropriate treatment for adults with spinal deformity (ASD Consensus)

Principal investigator:

Sigurd Berven

Co-Principal investigators:

Marinus de Kleuver

Goals:

Aim was to identify goals of care and management strategies that are appropriate for adult spinal deformity patients based upon worldwide expert opinion

Documents:

Publication summary
An international consensus on the surgical treatment standards for adolescent idiopathic scoliosis (AIS Consensus)

Principal investigator:

Marinus de Kleuver

Co-Principal investigators:

Manabu Ito

Goals:

Aim was to investigate what constitutes optimal operative care for adolescent idiopathic scoliosis patients between 12 and 20 years of age with curves ranging from 40 to 90 degrees Cobb angle

Documents:

Publication summary
AO Spine Comprehensive Classification of Adult Spinal Deformity (AOASD)

Principal investigator:

J Naresh-Babu

Co-Principal investigators:

Manabu Ito, Jong-Beom Park, Kenny Kwan

Goals:

Aims to develop comprehensive classification that separates patients into clinically different subgroups that require different treatment strategies

Documents:

AO Spine ASD Patient Profile
* Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK 1): five-year extension

A prospective, observational, multi-center study

Principal investigator:

Lawrence Lenke

Co-Principal investigators:

Michael Fehlings

Goals:

Aims to establish the long-term risk of neurologic deficit related to the surgical correction of adult spinal deformity and to identify characteristics associated with an increased risk of neurologic complications related to surgery at five-year postoperative

ClinicalTrials.gov Identifier: NCT02949245

* This AO Spine-sponsored study is executed with support from AO Clinical Investigation and Documentation (AO CID).

** Award-winning project

KF Deformity Steering Committee

KF Advisory Board

KF Deformity Associate Members

Christopher Ames, University of California San Diego, San Diego, CA, USA
Saumyajit Basu, Kothari Medical Center and Park Clinic, Kolkata, India
Anastasios Charalampidis, Karolinska University Hospital, Solna, Sweden
André Luis Fernandes Andújar, Hospital Infantil Joana de Gusmão, Florianópolis, Brazil
Munish Gupta, Washington University School of Medicine, St. Louis, MO, USA
So Kato, The University of Tokyo, Tokyo, Japan
Eric Klineberg, University of California, Davis, Sacramento, CA, USA
Kenny Kwan, The University of Hong Kong, Hong Kong
Christopher Nielsen, Toronto Western Hospital, Toronto, Canada
Ferran Pellisé, Spine Unit Vall d'Hebron, Barcelona, Spain
Zeeshan Sardar, Columbia University, New York, NY, USA
Miranda van Hooff, Radboud University Medical Center/Sint Maartenskliniek, Nijmegen, Netherlands
Yilgor Caglar, Acibadem Maslak Hospital, Istanbul, Turkey
Alekos Theologis, University of California San Francisco, San Francisco, CA, USA
Anna Rienmueller, Medizinische Universität Wien, Wien Austria
Brett Rocos, Duke University Medical Center, Durham, USA
Colby Oitment, McMaster University, Hamilton Ontario, Canada
Federico Landriel, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Swamy Ganesh, University of Calgary, Calgary, Canada
Yoshida Go, Hamamatsu University School of Medicine, Tokyo, Japan
Shen Jianxiong, Peking Union Medical College Hospital, Beijing, China
John Street, Vancouver General Hospital, Vancouver General Hospital, Canada
Juan Uribe, Barrow Neurological Institute, Phoenix AZ, USA
Kristen Jones, University of Minnesota, Minneapolis MN, USA
Thorsten Jentzsch, Balgrist Universitätsklinik, Zürich, Switzerland
Zhu Zezhang, Nanjing University Medical School, Nanjing, China
Jeffrey Hills, UT Health San Antonio, San Antonio, USA
Juan Sardi, University of Texas Southwestern Medical Center, Texas, USA
Elias Elias, University of Texas, Texas, USA
Jonathan Sembrano, University of Minnesota Medical School, Minnesota MN, USA
Aaron J. Buckland, Melbourne Orthopaedic Group Australia, Melbourne Australia

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