AO Spine Knowledge Forum SCI launches RECODE 2.0 to help end disability in DCM

The highly successful international research initiative AO Spine RECODE-DCM has been renewed for a second instalment. RECODE-DCM 2.0 will explore in detail some of the research priorities identified by its predecessor to boost the science and understanding around Degenerative Cervical Myelopathy. The project also aims to strengthen the global network of healthcare professionals, educators, and academics dedicated to treating, studying, and teaching about DCM.

The award-winning, multicenter, prospective study that partnered with the Scoliosis Research Society (SRS) aimed to establish the risk of neurologic deficit related to surgical correction of adult spinal deformity and to identify characteristics associated with increased risk of neurologic complications related to the surgery. According to Co-principal Investigator Michael Fehlings “Researchers and clinicians will now continue to build upon its findings, refining techniques and developing innovative strategies to reduce risk and improve patient outcomes.”

Final publication: five-year follow-up outcomes

The latest and final publication from the Scoli-RISK study, titled ‘Long-term follow-up of non-neurologic and neurologic complications after complex adult spinal deformity surgery: results from the Scoli-RISK-1 study’, was published in the European Spine Journal. This publication focused on the five-year follow-up data, detailing long-term adverse events and patient-reported outcomes.

The findings reinforce the importance of continued surveillance of patients beyond the early postoperative period. While immediate complications are often the focus of surgical literature, this study demonstrated that neurologic issues and other complications may manifest or persist years after surgery, necessitating a paradigm shift in postoperative care strategies.

A landmark study in ASD surgery from the AO

The Scoli-RISK study stands out for its extensive scale and rigorous methodology. 272 patients were enrolled from 15 centers across three continents, making it one of the most comprehensive investigations into neurologic complications following ASD surgery. The study followed patients for five years postoperatively, providing invaluable long-term data on outcomes, complications, and patient-reported quality of life measures.

Through its findings, the study has had a profound impact on surgical practices and contributed significantly to the body of knowledge surrounding complex spinal deformity procedures. With 17 peer-reviewed publications and 70 conference presentations, the study has become a cornerstone in ASD surgical research.

Key findings: risk factors and long-term outcomes

One of the most significant contributions of the Scoli-RISK study has been the identification of key risk factors for poor surgical outcomes. These include patient-specific elements such as age, comorbidities, and baseline neurological status, as well as surgical factors like operative time, blood loss, and the extent of spinal correction performed.

Among the study’s notable conclusions was the impact of mechanical complications on long-term outcomes. The findings highlighted how instrumentation failure, implant-related complications, and the necessity for revision surgeries could directly influence neurologic function and overall patient satisfaction. This underscores the need for improved mechanical stabilization strategies and reinforces the importance of careful surgical planning to mitigate these risks.

Regional variations highlight the need for standardization

The Scoli-RISK study revealed regional variations in outcomes and treatment protocols. Across different centers and continents, disparities were noted in surgical approaches, postoperative care, and complication rates.

These regional variations emphasize the need for greater standardization in surgical practices for ASD correction. By harmonizing best practices globally, the study suggests that surgeons can minimize neurologic complications and improve overall patient safety and satisfaction.

The role of Patient-Reported Outcome Measures (PROMS)

A critical takeaway from the Scoli-RISK study is the importance of patient-reported outcome measures (PROMs) in long-term follow-up. Traditional surgical success metrics often focus on radiographic correction and immediate postoperative outcomes. However, Scoli-RISK reinforces the value of longitudinal patient feedback on pain levels, functional improvement, and quality of life.

By utilizing PROMs, Scoli-RISK was able to capture the full spectrum of patient experiences, revealing insights into how neurologic complications affect daily life beyond clinical assessments. This patient-centered approach is essential in shaping future ASD treatment protocols and ensuring that success is defined not just by surgical precision, but by tangible, long-term patient benefits.

Implications for future clinical practice

The Scoli-RISK study has laid the groundwork for future research and clinical improvements in ASD surgery. Among its most pressing implications are:

Preoperative risk stratification: The study reinforces the need for comprehensive risk assessments before surgery. Measures such as advanced imaging, neuromonitoring strategies, and predictive analytics can help anticipate and mitigate complications.
Surgical technique optimization: Given the mechanical complications identified, the study highlights the necessity of adopting innovative fixation strategies and biomechanical reinforcement techniques to improve construct durability.
Enhanced postoperative monitoring: The five-year data underscores that patient care must extend well beyond the initial postoperative period. Standardizing long-term follow-up with both clinical assessments and PROMs is essential for ensuring continued patient well-being.
Global standardization efforts: The study’s identification of regional variations signals the need for international consensus guidelines to unify best practices and improve patient safety worldwide.
Focus on preventative measures: With neurologic complications being a major concern, proactive strategies such as intraoperative neuromonitoring, targeted rehabilitation, and early intervention protocols should be prioritized in surgical planning.

Looking forward

The Scoli-RISK study is clearly one of the most significant contributions to ASD surgical literature in recent years and has set a new benchmark for evaluating neurologic complications in spinal deformity surgery.

With its vast dataset and impactful insights, this study will serve as a foundation for future advancements in spinal deformity correction. The hope is that by integrating these findings into everyday clinical practice, the global surgical spine community can enhance safety, reduce complications, and ultimately improve the lives of patients undergoing complex spinal deformity surgeries.