AO CMF BOOST—Clinical Priority Program

Translational approaches for bone constructs: their impact on facial bone reconstruction

 

AO CMF BOOST

Pillars of the AO CMF BOOST—Clinical Priority Program

  • Bone regeneration
  • Materials for bone regeneration
  • Immune regulation/reaction
  • In vivo analysis / Proof of concept
  • Education
  • Material testing process
  • Mechanism of action
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  1. Ligorio C., Tavasoli E., Karaman-Jurukovska N., Ittycheri A., Wu Y., Kotowska A.M, Scurr D.J., Gupta S.A., Moogan L.V., Emmetsberger J., Lu F., German G.K., Mata A., Mammone T. (2024). Non-Invasive Monitoring of Palmitoyl Hexapeptide-12 Interaction with Human Skin Layers and Its Cosmetic Skincare Benefits. ACS Applied Bio Materials (Accepted). 
  2. Padilla-Lopategui S*., Ligorio C*., Bu W., Laurenza D., Redondo-Gomez R., Owens R., Iskratsch T., Sun H., Rose F., Mata A. (2024). Biocooperative regenerative materials by harnessing blood-clotting and peptide self-assembly. Advanced Materials, 2407156. https://doi.org/10.1002/adma.202407156. *Equal contribution. 
  3. Ligorio C., Martinez Espuga M., Laurenza D., Hartley A., Rodgers C.B., Kotowska A.M., Scurr D.J., Dalby M.J., Ordóñez-Morán P., Mata A. (2024). Disassembly of Self-Assembling Peptide Hydrogels as a Versatile Method for Cell Extraction and Manipulation. J Materials Chemistry B, 12, 11939-11952, https://doi.org/10.1039/D4TB01575D. 
  4. Murphy J.F., Lavelle M., Asciak L., Burdis R., Levis H., Ligorio C., McGuire J., Polleres M., Smith P., Tullie L., Uribe-Gomez J., Chen B., Dawson J., Gautrot J., Hooper N., Kelly D., Li V., Mata A., Pandit A., Phillips J., Shu W., Stevens M., Williams R., Armstrong J., Huang Y.Y.S. (2024). Biofabrication and Biomanufacturing in Ireland and the UK - Frontier Research for Industry 4.0. Bio-Design and Manufacturing 7(6), 825-856 https://doi.org/10.1007/s42242-024-00316-z. 
  5. Ligorio C., Kotowska A., Scurr D.J., Tavasoli E., Karaman-Jurukovska N., Mata A., Moogan L., German G., Lu F., Mammone T. (2024). 084 Cosmetic peptide penetration and assembly in human skin: A label-free approach, Journal of Investigative Dermatology, 144, 8, Supplement. https://doi.org/10.1016/j.jid.2024.06.100. 
  6. Watts J.A., Ligorio C., Mata A., Fay M.W. Direct detection camera as an alternative to negative staining for peptide structure determination. Proceedings of the Microscience Microscopy Congress 2023, incorporating EMAG 2023. www.doi.org/10.22443/rms.mmc2023.238. 
  7. Ligorio C., Mata A. (2023). Synthetic extracellular matrices with function-encoding peptides, Nature Reviews Bioengineering, 1:518–536. https://doi.org/10.1038/s44222-023-00055-3. 

 

 

  1. European Society for Biomaterials (ESB), Turing, Iraly, September 6-9, 2025. Keynote lecture.
  2. Tissue and Cell Engineering Society (TCES), Bristol, UK, June 18-20, 2025. Plenary lecture.
  3. Peptide Materials, Gordon Research Conference (GRC), Pomona, California, January 19-24, 2025.
  4. NIHR MSK, Surgery, Inflammation and Recovery Conference, 3rd October 2024, Nottingham, UK. “Designing Functional Bone Marrow Niches”
  5. BioMedEng24 at Queen Mary University of London, 5th – 6th September 2024, London, UK. “New tissue engineering opportunities of fibrin materials via innovative assembling and biofabrication strategies”
  6. BioMedEng Conference 2024, London, UK, September 5, 6, 2024. Keynote lecture.
  7. Master in Medical Technologies, Applied Biomaterials and Nanotechnologies: Biomaterials development and analytical technologies, 3rd June 2024, Università del Piemonte Orientale, Novara, Italy. “Peptides as molecular building blocks for regenerative biomaterials”
  8. World Biomaterials Congress, Daegu, Republic of Korea, May 29, 2024. Keynote lecture.
  9. World Biomaterials Congress, Daegu, Republic of Korea, May 27, 2024. Invited talk.
  10. Materials Research Society (MRS) Fall Meeting, Boston, November 30 – December 5, 2023. Keynote lecture.
  11. 14th Berlin School for Regenerative Therapies (BRST) Symposium, 6th - 8th December 2023, Berlin, Germany. “Designing multifunctional biomaterials through peptide-protein co-assembly and acoustic fabrication”
  12. The Regenerative Games: Uniting the Worlds of Tissue Regeneration in Berlin, December 7, 2023. Invited talk.
  13. BDI Annual Research Symposium, Talk for the "Regenerating & Modelling Tissues" Theme, 22nd September 2023, Nottingham, UK. “Harnessing peptide-protein co-assembly to engineer multifunctional biomaterials”
  14. 3rd Midlands Materials Chemistry Meeting, 27th July 2023, Nottingham, UK. “Harnessing peptide-protein co-assembly to engineer multifunctional biomaterials”.
  15. Tissue Engineering and Regenerative Medicine International Society (TERMIS), Manchester, UK, March 28-31, 2023. Keynote lecture.
  16. First Summer School of SUPRALIFE EU: Functional Supramolecular Polymeric Biomaterials, Aveiro, Portugal, March 19-21, 2023. Plenary lecture.
  17. VI RSEQ Chemical Biology Group Meeting – ChemBioVI, Valencia, March 6-8, 2023. Invited talk.

 

 

  1. NIHR Musculoskeletal, Surgery, Inflammation and Recovery Theme Meeting, 23rd November 2023, Nottingham Biomedical Research Centre, Nottingham, UK. “Harnessing peptides to engineer regenerative biomaterials”
  2. BDI Annual Research Symposium, 22nd September 2023, Nottingham, UK. “Harnessing peptides to engineer regenerative biomaterials”

 

 

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Grants acquired resulting from AO CMF work

  1. EPSRC
    1. Research and Partnership Hub for Health Technologies in Manufacturing Stem Cells (Mainstream)
    2. January 2025 – December 2029
    3. £11M. Our group receives £150,000
  2. Human Frontier Science Program
    1. 3D-Bioprinting Meets Machine Learning: A Novel Tool for Decipher the Determinants of Viral Tropism
    2. January 2025 – December 2027
    3. £350,000. Our group receives £90,000
  3. Nottingham Biomedical Research Center (NIHR-BCR)
    1. Development of an in vitro model for athrofibrosis
    2. January 2024 – December 2025
    3. Our group receives £80,000

 

Video presenting the project

Consortium team

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