Norian CRS Fast Set Putty

Traumatic and surgically created defects in the craniofacial skeleton often require filling with a synthetic material for optimum clinical outcomes. Norian CRS (craniofacial repair system) Fast Set Putty offers a treatment solution for such cases. The Norian CRS family of products is completely synthetic self-setting calcium phosphate cements which closely resemble the mineral phase of bone. Once cured, both materials have identical chemistries and are gradually resorbed and replaced with bone during the bone remodeling process. The key difference between the two formulations is in the intraoperative handling and delivery properties.

Norian Fast Set Putty is a more rapidly setting version of the product (sets in 36 minutes) which also has greater viscosity. These features give the product enhanced moldability and contourability once placed in the surgical site. Norian Fast Set Putty comes packaged in two components; a cup containing a sterile powder (calcium phosphate) and a vial containing sterile solution (dilute sodium phosphate). The two components are combined and mixed by hand using the spatula included. After mixing for 4590 seconds, the material is ready to be delivered to the site.

Features and benefits

The Norian CRS line of products hardens in a warm and wet environment, reducing the need to control moisture at the surgical site. The materials undergo in situ isothermal hardening, thereby eliminating thermal injury to the surrounding tissues. Both materials also achieve maximum compressive stress values which exceed that of native cancellous bone after 24 hours of hardening.

Clinical success

Norian CRS has been in clinical use for nearly a decade, with a large number of patients successfully treated by the use of this product. The more recently developed Norian CRS Fast Set Putty has also enjoyed widespread clinical success while expanding treatment options available to surgeons.

Clinical indications

Norian CRS Fast Set Putty is indicated for filling or repairing craniofacial defects and craniotomy cuts with a surface area no larger than 25 cm2. The material is also indicated for the restoration or augmentation of bony contours of the craniofacial skeleton, including the fronto-orbital, malar, and mental areas. The product is not intended for use in the spine, and should not be used in the presence of infection. Clinical procedures appropriate for the use of Norian CRS products include:

  • Cranioplasty
  • Cranial recontouring
  • Cranial flap augmentation
  • Augmentation genioplasty
  • Onlay grafting
  • Skull base defect repair


Figure Norian CRS Fast Set Putty components.

Figure Norian CRS Fast Set Putty being applied to a cranial defect.

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