Biomaterial Associated Infection – Immunological Aspects and Antimicrobial Strategies
12 December 2012
Fintan Moriarty of AO Research Institute Davos, along with Dutch collaborators Henk Busscher and Sebastian AJ Zaat, has recently completed editing a book entitled Biomaterial Associated Infection: Immunological Aspects and Antimicrobial Strategies. The book has been published by Springer Publishing and includes contributions from AO Research Institute Davos director Geoff Richards, as well as from past AO Research Institute Davos medical research fellows Lorenzo Calabro, Abhay Gahukamble, Ahmed Seif El Din and Cameron Lutton.
Infection has become one of the core themes within AO Research Institute Davos's research under the AO Trauma clinical division. This book provides an overview of this problem, focusing both upon research and clinical issues.
Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function.
With an aging society, and increasing use of biomaterials to ensure restoration of function and quality of life, the problem of BAI may be expected to increase in the coming decades. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial.
In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described, alongside a discussion of the utility of these devices and perspectives for future development.
This book is aimed at clinicians and researchers across all disciplines who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.