Our achievements

Since our most recent transformation in 1999, the AO Clinical Investigation and Documentation Institute (AO CID), has conducted more than 100 clinical studies engaging over 350 clinics in 45 countries and enrolled more than 10,000 patients. Between 2010 and 2018, AO Clinical Investigation and Documentation has published over 300 peer-reviewed scientific articles and numerous presentations.

Such achievements are the backbone of our claim: More than opinions. Evidence.


AO Clinical Investigation and Documentation current studies

  • AO Spine

    Project title (short title)

    Principal Coordinating
    Investigator

    Clin.Trial.gov
    NCT number

    Current Phase

    The epidemiology, process and outcomes of spine oncology (EPOSO)

    Charles Fisher

    n/a

    Monitoring

    Spinal deformity intraoperative monitoring: understanding and managing intraoperative neuromonitoring changes during spinal deformity surgery (SDIM)

    Stephen Lewis

    NCT03880292

    Planning

    Prospective evaluation of elderly deformity surgery (PEEDS)

    Stephen Lewis

    NCT02035280

    Monitoring

    Metastatic tumor research and outcomes network: a multicenter prospective registry for the management of metastatic spine tumors (MTRON)

    Charles Fisher

    NCT02830451

    Monitoring

    Primary tumor research and outcomes network: A multicenter prospective registry for the management of primary tumors of the spine (PTRON)

    Charles Fisher

    NCT02790983

    Monitoring

    Evaluation of neurologic complications associated with surgical correction of adult spinal deformity (Scoli-RISK-1)

    Lawrence Lenke

    NCT01305343

    Publication

    Evaluation of neurologic complications associated with surgical correction of adult spinal deformity: 5-year follow-up extension (Scoli-RISK-1-extension)

    Lawrence Lenke

    NCT02949245

    Monitoring

    Spine registry to collect outcome measures related to the disease status of patients with dpine disorders (DegenPRO)

    Tim Yoon

    NCT02802033

    Monitoring

    Thoracolumbar burst fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment (Spine_TL-A3-A4)

    Marcel Dvorak

    NCT02827214

    Monitoring

    Prognostic factors and therapeutic effects of surgical treatment for traumatic spinal column iInjury with spinal cord injury (SCI POEM)

    Allard Hosman

    NCT01674764

    Monitoring

    Systematic literature research and review on biomaterials (allograft including DMB) used in cervical and lumbar fusion.

    Jim Youssef;
    Hans Jörg Meisel

    n/a

    Publication

    C-Classification

    Alex Vaccaro

    n/a

    Planning

  • AO Technical Commission Spine

    Project title (short title)

    Principal
    Coordinating
    Investigator

    Clin.Trial.gov
    NCT number

    Current Phase

    Evaluation of a growth guiding construct vs. standard dual growing rods and VEPTR for the treatment of early onset scoliosis patients: A prospective multi-center cohort study with a matched historical control. (TROLLEY)

    Jean Ouellet, MD, FRCSC

    NCT01672749

    Monitoring

  • AO Trauma

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov
    NCT number

    Current Phase

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty (PPFx Registry)

    Karl Stoffel

    NCT03378557

    Monitoring

    Implementation of a registry on bone infection to improve patient outcomes and research efforts (CPP Bone Infection Registry)

    Stephen Kates

    NCT01677000

    Analysis

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty (PPFx Registry)

    Karl Stoffel

    NCT03378557

    Monitoring

    A prospective multicenter cohort study to evaluate the benefit of the geriatric fracture center concept (GFC)

    Michael Blauth

    NCT02297581

    Analysis

    A prospective multicenter cohort study to evaluate the effect of early mobilization of patients after hip fracture fixation on functional outcomes in the Chinese population (MobiChina)

    Frankie Leung

    NCT02296086

    Analysis

    MobiChina survey

    Frankie Leung

    n/a

    Monitoring

    The role of patient expectations in traumatic orthopedic outcomes (TEFTOM Eurasia)
    TEFTOM: The trauma expectation factor trauma outcomes measure

    Reto Babst

    NCT01134354

    Publication

    Clinical Priority Program (CPP III pre-project prox humerus)

    Laurent Audigé

    n/a

    Analysis

    Clinical Priority Program (CPP) Patient Outcome Project I:
    Translation, Cultural Adaptation and Cognitive Debriefing of Extension Items of PROMIS Physical Function item bank V2.0 in German and Spanish

    Marilyn Heng, Claudia Hartmann

    n/a

    Planning

    Clinical Priority Program (CPP Patient Outcome Project II:
    GO FIT FAST - Gait Observation for Fully Individualized Treatment and Aftercare following Surgery and Trauma

    Benedikt Braun

    DRKS00012691 (preliminary)

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project III:
    Development of interpretation guidance for clinicians to better understand meaning of PROMIS scores

    Prakash Jayakumar, Marilyn Heng, Stephen Gwilym

    n/a

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project IV:
    Linking of PROMIS Physical Function to Legacy Measures in an Orthopaedic Patient Population

    Marilyn Heng (center 1),
    Tim Pohlemann, Benedikt Braun (Center 2), Prakash Jayakumar (Center 3)

    n/a

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project V:
    Norm Data - Collection of international Age-based Norm Data for interpretation of scores obtained from the newly extended PROMIS® Physical Function item bank version 2.0

    Matthias Rose

    n/a

    Planning

    Clinical Priority Program (CPP) Patient Outcome Project VI:
    Standard setting to develop PROMIS score severity threshold categories

    Marilyn Heng

    n/a

    Planning

    AO multicenter intervention trial to evaluate the impact of a bundle of measures for the prevention of surgical site infection in fracture patients (AOPOSSI)

    Stephen L. Kates

    NCT03380273

    Planning

    (LAMOS) Latin America hip fracture mortality study

    William Belangero

    NCT01650064

    Publication

     

  • AO Technical Commission Trauma

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    OpenGo Sensor Insole in open wedge HTO (Moticon - HTO)

    Stefan Döbele, Steffen Schröter

    NCT03222921

    Monitoring

    A prospective study to investigate postoperative real life weight bearing measured in patients treated with a Trochanter Fixation Nail Advanced (TFNA weight bearing)

    Michael Blauth, Karl Stoffel

    NCT03160508

    Monitoring

    A prospective multicenter observational registry for children up to 16 years of age with femur shaft fractures (PedFemFx)

    Peter Schmittenbecher, Unni Narayanan

    NCT03211546

    Monitoring

    A prospective case series study to monitor healing progression and real life weight bearing after tibial fracture using smart biofeedback systems (SmartFix II - Moticon)

    Stefan Döbele

    NCT03166267

    Monitoring

    Data collection with a novel biofeedback technology for continuous monitoring of bone healing (FR SmartFix)

    Dankward Hoentzsch

    NCT02094209

    Analysis

    A focused registry on the Femoral Neck System (FNS) in patients with femoral neck fractures (FR FNS)

    Karl Stoffel

    NCT02422355

    Monitoring

    A randomized multicenter study comparing the effectiveness of hemi versus total shoulder arthroplasty in patients with a degenerative joint disease (EPOCA)

    Norbert Suedkamp

    NCT01288066

    Monitoring

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty (PPFx Registry)

    Karl Stoffel

    NCT03378557

    Monitoring

    Quality of fracture reduction and its influence on functional results in patients with pilon fractures (Pilon)

    Christoph Sommer

    NCT01316289

    Publication

    Comparison of Proximal Femoral Nail Antirotation (PFNA) versus PFNA Augmentation for the treatment of closed unstable trochanteric fractures – A randomized-controlled trial (PFNA Augmentation)

    Christian Kammerlander

    NCT01473082

    Publication

    Prospective multicenter registry for use of the MAXFRAMETM Multiaxial Correction System (MAXFRAME)

    Teddy Slongo

    not registered yet

    Planning

    Locking plates for distal femur fractures – a multicenter case review
    A retrospective radiological analysis of the mechanical performance of different locking plates in distal femoral fractures (VA-LCP Case review)

    Mark Lee

    n/a

    Planning

    An international, multicenter, prospective registry to investigate treatment options and their outcomes on Long Bones Defects (LoBoDeRe)

    Christoph Pape

    not registered yet

    Planning

    Fracture-Related Outcome Study for operatively treated Tibia shaft fractures (FROST)

    Willem-Jan Metsemakers

    NCT03598530

    Planning

    Multicenter prospective registry for periprosthetic fractures after hip or knee arthroplasty (PPFx Registry)

    Karl Stoffel

    NCT03378557

    Monitoring

     

  • AO CMF

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    An international, multicenter, prospective registry to collect data of treatment patterns of patients with Medication-Related OsteoNecrosis of the Jaw (MRONJ) and their outcome (MRONJ registry)

    Risto Kontion (University of Helsinki) and Sven Otto (Ludwig-Maximilian University, Munich)

    NCT02932501

    Monitoring

    International, multicenter, prospective registry to collect data of treatment patterns in patients with bilateral condylar fracture (BCFx) of the mandible (BCFx registry)

    Risto Kontio (University of Helsinki) and Edward Ellis 3rd (University of Texas Health Science Center at San Antonio)

    NCT02884765

    Monitoring

    A Multicenter Randomized Controlled Clinical Investigation to Investigate the Treatment of Double (Bilateral) Mandibular Fractures (DMFx)

    Risto Kontio and Edward Ellis 3rd

    NCT02341443

    Monitoring

    Orbita 3 - Additional publication

     

    n/a

    Publication

    International, multicenter, prospective registry to collect data on orbital fractures (OFx), their treatment and outcome

    Eppo B. Wolvius

    TBD

    Planning

    International, multicenter, prospective registry to collect data in patients > 60 years suffering from mandibular fractures (MFx 60+)

    Risto Kontio

    TBD

    Planning

    International, multicenter, prospective registry to collect data of patients treated with alloplastic temporomandibular joint (TMJ) replacements

    Andreas Thor

    TBD

    Planning

     

  • AO Education Institute

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    Development of performance metrics for cephalomedullary nailing for unstable pertrochanteric fractures- phase 1 (Immpact)

    Anthony Gallagher

    TBD

    Montoring

     

  • AO Development Incubator

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    Retrospective data collection in patients treated with immobilization of the metacarpals and/or phalanges of the hand with external fixation with K-wires and the fixation block "K-Blocks" (K-Blocks)

    Karl Heinz Bürger

    TBD

    Planning

     

  • Collaboration with the AO Research Institute Davos (ARI)

    Project title (short title)

    Principal Coordinating Investigator

    Clin.Trial.gov NCT number

    Current Phase

    Clinical data collection with a novel biofeedback technology for continuous monitoring of bone healing (SmartFix I)

    Dankward Höntzsch

    NCT02094209

    Monitoring

    A prospective case series study to monitor healing progression and real life wieght bearing after tibial fracture using smart biofeedback systems (Moticon SmartFix II)

    Stefan Döbele

    NCT03166267

    Monitoring

    Next generation SmartFix-integration with implants (SmartPlate)

    n/a

    n/a

    Idea



AO Clinical Investigation and Documentation completed studies

  • AO CMF

    Project title
    (short title)

    Description/goals

    Principal Coordinating
    Investigator

    Clin.Trial.gov NCT number

    Orbita1

    Evaluation of orbital volume differences

       

    Orbita 3

    Prospective Multicenter Trial to Compare Preformed vs Non Preformed Orbital Implants (Orbita 3)

    Niels Gellrich

    NCT01121159

  • AO Trauma

    Project title
    (short title)

    Description/goals

    Principal Coordinating Investigator

    Clin.Trial.gov
    NCT number

    FFOB Hum

    The influence of local bone status on complications after surgical treatment of proximal humerus fractures

    Franz Kralinger, MD

    NCT01143675

    NonRandHum Comparison of conservative versus operative treatment of humerus shaft fractures. Prospective Cohort Study    
    PH Cons Documentation of the results of conservative treatment of proximal humeral fractures
       

    FFOB Rad

    The Influence of Local Bone Status on Complications After Surgical Treatment of Distal Radius Fractures

    Daniel A Rikli, PD

    NCT01144208

    CEA Chile Cost effectiveness analysis of scaphoid fractures in Chile
       

    Scaphoid

    Operative Versus Conservative Treatment of Scaphoid Fractures

    Markus Schaedel-Hoepfner, Prof. MD

    NCT00205985

    LAMOS Latin America Hip Fracture Mortality Study
    Wiliam Belangero, Dr. med
    NCT01650064

    SI Screw

    Accuracy of Navigation in Placement of Accuracy of Navigation in Placement of Sacroiliac Screw (SI Screw)

    Ulrich C. Stöckle, Prof. MD

    NCT00955565

    LFN Treatment of femoral fractures with the Expert™ Lateral Femoral Nail
       
    LISS-DF Minimal invasive Frakturstabilisierung von distalen Femurfrakturen mit dem LIS-System: Eine prospektive Multizenterstudie
       
    HTO Navi Prospective Study comparing the deviation from the leg-axis in navigated vs. non-navigated open-wedge high tibial osteotomies, receiving TomoFix®
       

    TEFTOM

    The role of patient expectations in traumatic orthopedic outcomes: the development of the trauma expectation factor trauma outcome measure (TEFTOM)

    Michael Suk, Professor

    NCT01126398

    UTN Protect Randomized controlled trial to evaluate the operative stabilization of closed and open diaphyseal fractures of the tibia using gentamicin-coated titanium nails (UTN/Expert TN + antibiotic coating®)
       
    MOXFQ TMT Fusion Plate vs. Two Crossed Screws (TMT)
    Ian Winson, MB ChB, FRCS
    NCT02096146

     

  • AO Spine

    Project title
    (short title)

    Description/goals

    Principal Coordinating
    Investigator

    Clin.Trial.gov
    NCT number

    CSM-I

    An Assessment of Surgical Techniques for Treating Cervical Spondylotic Myelopathy. International Multicenter Study

    Michael Fehlings, MD, PhD

    NCT00565734

    CSM

    An Assessment of Surgical Techniques for Treating Cervical Spondylotic Myelopathy. Retrospective Study

    Michael Fehlings, MD, PhD

    NCT00285337

    GOF

    Comparing Surgical to Conservative Management in the Treatment of Type II Odontoid Fractures Among the Elderly

    Alexander R Vaccaro, MD

    NCT00266929

    ScoliRisk 1

    Neurologic Complications in Spinal Deformity Surgery

    Lawrence Lenke, MD

    NCT01305343

    PAM

    Posterior ligament complex assessment without magnetic resonance image in thoracolumbar fractures (T11-L2): A diagnostic test study to analyze sensitivity and specificity (PAM) .

    Shanmuganathan Rajasekaran 

    NCT02950532

     

  • AO Technical Commission

    Project title
    (short title)

    Description/goals

    Clin.Trial.gov
    NCT number

    LPHP

    LPHP-Philos-PHN Conservative Treatment

    NCT00205959

    NonRandHum

    Comparison of conservative versus operative treatment of humerus shaft fractures. Prospective Cohort Study

     

    PH Cons

    Documentation of the results of conservative treatment of proximal humeral fractures

     

    PHILOS+

    A Multicenter Randomized Controlled Trial to Investigate the Treatment Outcome of PHILOS Screw Augmentation Compared to PHILOS Without Augmentation in Older Adult Patients With Proximal Humerus Fractures

    NCT01847508

    LCP DR 2.4mm

    Surgical Plate Osteosynthesis of Distal Radius Fractures: Prospective study of the Locking Compression Plate (LCP DR 2.4mm)

     

    LCP DR 3.5mm

    Surgical Plate Osteosynthesis of Distal Radius Fractures: Prospective study of the Locking Compression Plate (LCP DR 3.5mm)

     

    LCP DR Cons

    Conservative treatment with or without reduction of distal radius fractures

     

    LCP DR Retro

    Distal radius fracture treatment. A retrospective study

    LCP-FU Series

    Evaluation of the safety of the LCP design on the outcome of fracture treatment

     

    VA LCP DR - Variable Angle LCP Distal Radius

    2.4 mm Variable Angle LCP Two-Column Volar Distal Radius (VALCP2010)

    NCT01103297

    FR TFNA

    A Focused Registry on the Titanium Trochanter Fixation Nail Advanced (TFNAdvanced™) - TFNA System in Patients With Proximal Inter-, Per- or Subtrochanteric Fractures

    NCT02305121

    SI Screw

    Accuracy of Navigation in Placement of Accuracy of Navigation in Placement of Sacroiliac Screw

    NCT00955565

    LFN

    Treatment of femoral fractures with the Expert™ Lateral Femoral Nail

     

    Pilon

    Pilon Fracture Reduction and Functional Outcome

    NCT01316289

    Infection India

    Infection Rates Following Internal Fixation of Open and Closed Tibia Fractures in India

    NCT01691599

    ProFHER

    ProFHER Trial critical appraisal (ProFHER)

     

    (FR QSP)

    A prospective and retrospective, multicenter registry for surgeon-based evaluation of the "Quadrilateral Surface Plate" used for acetabular fractures (FR QSP)

    NCT01839565

     

  • AO Education Institute

    Project title
    (short title)

    Description/goals

    Clin.Trial.gov
    NCT number

    PI-Program

    Optimizing intraoperative imaging during proximal femur fracture fixation- a performance improvement program for surgeons

     

  • AO Research Institute

    Project title
    (short title)

    Description/goals

    Principal Coordinating
    Investigator

    Clin.Trial.gov
    NCT number

    SmartFix I

    Clinical data collection with a novel biofeedback technology
    for continuous monitoring of bone healing

    Dankward Höntzsch

    NCT02094209


AO Clinical Investigation and Documentation peer-reviewed publications

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