Sibylle Grad – Musculoskeletal Regeneration

Sibylle Grad

Dr. Sibylle Grad
Principal Scientist

Clavadelerstrasse 8
7270 Davos, Switzerland

Tel.: +41 81 414 24 80
Fax: +41 81 414 22 88



Dr Sibylle Grad is a Principal Scientist and Deputy Program Leader in the Musculoskeletal Regeneration Program of the AO Research Institute Davos. Within the Musculoskeletal Regeneration Program she is the focus area leader for intervertebral disc and cartilage research.

Dr Grad obtained her degree in Pharmacy and her PhD in Natural Sciences from the Department of Cell Biology of the Federal Institute of Technology (Eidgenössische Technische Hochschule, ETH) in Zürich. After completing her first post-doctoral training she joined the AO Research Institute Davos in 2000. Dr Grad has since then acquired extensive research expertise in the field of tissue engineering and regenerative medicine with particular focus on articular cartilage and intervertebral disc repair and regeneration.

Current Research Topics

Intervertebral disc degeneration and regeneration

  • Whole organ culture models and bioreactors for degenerative and inflammatory disc disorders
  • Cell therapy, molecular therapy, stem/progenitor cell homing for disc regeneration
  • Annulus fibrosus repair
  • Phenotype markers and systemic biomarkers for disc degeneration

Articular cartilage repair and regeneration

  • Bioreactors mimicking load and motion within articulating joints
  • In vitro explant models for chondral and osteochondral defects
  • Cell therapy, molecular therapy and tissue engineering for articular cartilage repair
  • Physical stimulation for cartilage repair

Dr Grad has supervised a number of Doctoral and Masters Theses and is a docent and course leader in the graduate program of the Department of Health Science and Technology (D-HEST) at the ETH Zürich. In addition she has obtained funding from national, European and international agencies (SNSF, FP7, H2020, NASS, SET, SSSTC), and has been partner and section leader of several collaborative projects in the areas of disc and cartilage research.

Dr Grad is an International Editorial Board member of the European Cells & Materials (eCM) Journal and co-organiser of eCM Annual Conference. She has co-organized the Spine Research Interest Group of the Orthopaedic Research Society (ORS), was ORS Program Committee Member from 2014-2016, and has been appointed ORS Spine Section Research Chair for the term 2017-2019. She is also an active member of AOSpine International and the AOSpine Research Network, a Fellow of the International Cartilage Repair Society (ICRS), active member of the Tissue Engineering and Regenerative Medicine International Society (TERMIS), and the F1000 Medicine section.

Her publications include more than 75 peer reviewed papers and 7 book chapters.

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