Sibylle Grad – Musculoskeletal Regeneration

Sibylle Grad

Dr. Sibylle Grad
Principal Scientist

Clavadelerstrasse 8
7270 Davos, Switzerland

Tel.: +41 81 414 24 80
Fax: +41 81 414 22 88



Dr Sibylle Grad is a Principal Scientist and Deputy Program Leader in the Musculoskeletal Regeneration Program of the AO Research Institute Davos. Within the Musculoskeletal Regeneration Program she is the focus area leader for intervertebral disc and cartilage research.

Dr Grad obtained her degree in Pharmacy and her PhD in Natural Sciences from the Department of Cell Biology of the Federal Institute of Technology (Eidgenössische Technische Hochschule, ETH) in Zürich. After completing her first post-doctoral training she joined the AO Research Institute Davos in 2000. Dr Grad has since then acquired extensive research expertise in the field of tissue engineering and regenerative medicine with particular focus on articular cartilage and intervertebral disc repair and regeneration.

Current Research Topics

Intervertebral disc degeneration and regeneration
- Whole organ culture models and bioreactors for disc degeneration and regeneration
- Cell therapy, molecular therapy, stem/progenitor cell homing for disc regeneration
- Biomarkers for disc degeneration

Articular cartilage repair and regeneration
- Cell therapy, molecular therapy and tissue engineering for articular cartilage repair
- Physical stimulation for cartilage repair
- In vitro models and bioreactors

Dr Grad has supervised a number of Doctoral and Masters Theses and is a docent and course leader in the graduate program of the Department of Health Science and Technology (D-HEST) at the ETH Zürich. In addition she has obtained funding from national, European and international agencies (SNSF, FP7, H2020, NASS), and has been partner and section leader of several collaborative projects in the areas of disc and cartilage research.

Dr Grad is an International Editorial Board member of the European Cells & Materials (eCM) Journal and co-organiser of eCM Annual Conference. She has co-organized the Spine Research Interest Group of the Orthopaedic Research Society (ORS) and is ORS Program Committee Member for the term 2014-2016. She is also active member of AOSpine International and the AOSpine Research Network, the International Cartilage Repair Society (ICRS), the Tissue Engineering and Regenerative Medicine International Society (TERMIS), and the F1000 Medicine section.

Her publications include more than 65 papers and 5 book chapters. 

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